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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Caspase-3 Polyclonal Antibody 2

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货号 TMAB-03661

Anti-Caspase-3 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Caspase-3。Anti-Caspase-3 Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Caspase-3 Polyclonal Antibody 2

Anti-Caspase-3 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-03661

Anti-Caspase-3 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Caspase-3。Anti-Caspase-3 Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF。

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50 μL
¥ 1,165
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100 μL
¥ 1,975
5日内发货
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产品介绍

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产品描述
Anti-Caspase-3 Polyclonal Antibody 2 is a Rabbit antibody targeting Caspase-3. Anti-Caspase-3 Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:1000-5000; IHC-P: 1:200-800; IHC-Fr: 1:200-800; IF: 1:200-800
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
抗原信息
免疫原
Recombinant Protein: human Caspase-3
抗原种属
Human
基因名称
CASP3
基因ID
836
蛋白名称
Caspase-3
Uniprot ID
P42574
功能
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
化学信息
分子量Theoretical: 32 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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