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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-Caspase-3 Antibody (6S481)

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货号 TMAC-00082

别名 Yama, SCA-1, CPP32B, CPP32, apopain

Anti-Caspase-3 Antibody (6S481) 是一种 Rabbit 抗体，靶向 Caspase-3。Anti-Caspase-3 Antibody (6S481) 可用于 IHC,IP,WB。

Anti-Caspase-3 Antibody (6S481)

Anti-Caspase-3 Antibody (6S481)

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Rating icon 还可以
货号 TMAC-00082 别名 Yama, SCA-1, CPP32B, CPP32, apopain

Anti-Caspase-3 Antibody (6S481) 是一种 Rabbit 抗体，靶向 Caspase-3。Anti-Caspase-3 Antibody (6S481) 可用于 IHC,IP,WB。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

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产品描述
Anti-Caspase-3 Antibody (6S481) is a Rabbit antibody targeting Caspase-3. Anti-Caspase-3 Antibody (6S481) can be used in IHC,IP,WB.
别名Yama, SCA-1, CPP32B, CPP32, apopain
Ig Type
IgG
克隆号
6S481
反应种属
Human
验证活性
1. Western blot analysis of active+pro Caspase 3 on Jurkat cells lysates using anti-active+pro Caspase 3 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-active+pro Caspase 3 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-active+pro Caspase 3 antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-active+pro Caspase 3 antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-active+pro Caspase 3 antibody. Counter stained with hematoxylin.
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应用IHCIPWB
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Caspase-3, also known as apopain, SCA-1, Yama and CPP32, is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp175-Ser176 to produce the p11 subunit and the p20 peptide. Subsequently, the p20 peptide is cleaved at Asp28-Ser29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 subunits. At the onset of apoptosis, caspase-3 proteolytically cleaves PARP at an Asp216-Gly217 bond. During the execution of the apoptotic cascade, activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6, -7 and -9. The human caspase-3 gene encodes a cytoplasmic protein that is highly expressed in lung, spleen, heart, liver, kidney and cells of the immune system.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P42574
化学信息
分子量Theoretical: 35 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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