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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Caspase-10 Polyclonal Antibody 3

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货号 TMAB-03653

Anti-Caspase-10 Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 Caspase-10。Anti-Caspase-10 Polyclonal Antibody 3 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Caspase-10 Polyclonal Antibody 3

Anti-Caspase-10 Polyclonal Antibody 3

一键复制产品信息
Rating icon 还可以
货号 TMAB-03653

Anti-Caspase-10 Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 Caspase-10。Anti-Caspase-10 Polyclonal Antibody 3 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,965
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200 μL
¥ 2,795
5日内发货
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产品介绍

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产品描述
Anti-Caspase-10 Polyclonal Antibody 3 is a Rabbit antibody targeting Caspase-10. Anti-Caspase-10 Polyclonal Antibody 3 can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
组织特异性Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. Post-translational modifications : Cleavage by granzyme B and autocatalytic activity generate the two active subunits. Phosphorylated upon DNA damage, probably by ATM or ATR.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Caspase-10
抗原种属
Human
基因名称
CASP10
基因ID
843
蛋白名称
Caspase-10
Uniprot ID
Q92851
功能
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.
化学信息
分子量Theoretical: 22/59 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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