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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-CALR Monoclonal Antibody (1B416)

Synonyms: SSA, RO, HEL-S-99n, CRT, cC1qR, CALR1
货号 TMAT-0204 一键复制产品信息
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Anti-CALR Monoclonal Antibody (1B416) 是一种 Mouse 抗体，靶向 CALR。Anti-CALR Monoclonal Antibody (1B416) 可用于 WB,IHC,IF,FCM。

Anti-CALR Monoclonal Antibody (1B416)

一键复制产品信息
Rating icon 还可以
货号 TMAT-0204

别名 SSA, RO, HEL-S-99n, CRT, cC1qR, CALR1

Anti-CALR Monoclonal Antibody (1B416) 是一种 Mouse 抗体，靶向 CALR。Anti-CALR Monoclonal Antibody (1B416) 可用于 WB,IHC,IF,FCM。

Anti-CALR Monoclonal Antibody (1B416)
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产品介绍

生物活性
产品描述
Anti-CALR Monoclonal Antibody (1B416) is a Mouse antibody targeting CALR. Anti-CALR Monoclonal Antibody (1B416) can be used in WB,IHC,IF,FCM.
别名
SSA, RO, HEL-S-99n, CRT, cC1qR, CALR1
Ig Type
IgG2a
克隆号
1B416
反应种属
Human,Mouse,Rat,Rabbit
应用WBIHCIFFCM
推荐剂量
WB: 1/500-1/2000; IHC: 1/100-1/500; IF: 1/50-1/500; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液Ascitic fluid containing 0.03% sodium azide
浓度1 mg/ml
研究背景Calreticulin, also known as RO, CRT, SSA, cC1qR, FLJ26680, CALR. Entrez Protein NP_004334. It is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Synthetic peptide corresponding to aa (EEEDVPGQAKDELC) of human Calreticulin, conjugated to KLH.
抗原种属
Human
基因名称
CALR
基因ID
811
蛋白名称
Calreticulin
Uniprot ID
P27797
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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