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Anti-CADM2 Polyclonal Antibody

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货号 TMAB-03551

Anti-CADM2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CADM2。Anti-CADM2 Polyclonal Antibody 可用于 WB。

Anti-CADM2 Polyclonal Antibody

Anti-CADM2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-03551

Anti-CADM2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CADM2。Anti-CADM2 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-CADM2 Polyclonal Antibody is a Rabbit antibody targeting CADM2. Anti-CADM2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Ig (immunoglobulin) superfamily members exhibit functional characteristics including immune responses, growth factor signaling and cell adhesion. IGSF4D (Ig superfamily member 4D) is also known as CADM2 (cell adhesion molecule 2), Necl-3 (nectin-like protein 3) or synCAM2 and is a 435 amino acid protein that is a member of the nectin family. IGSF4D contains two C2-type domains and one V-type domain, which are characteristic of the nectin family and are thought to function in molecular recognition. IGSF4D is expressed in many tissues, including brain, where it is detected in the nervous system, specifically in myelinated axons and ependymal cells. IGSF4D is localized to the plasma membrane as a single-pass membrane protein and is expressed as three isoforms. IGSF4D functions in the regulation of cell–cell adhesion by homophilic and heterophilic interactions leading to cell aggregation. These interactions are also important for neuron–neuron or neuron–glia associations, which are important for the development and function of the central nervous system. IGSF4D is downregulated in lung cancer, suggesting a possible role in tumor suppression.
抗原信息
免疫原
KLH conjugated synthetic peptide: human CADM2
抗原种属
Human
基因名称
CADM2
基因ID
253559
蛋白名称
Cell adhesion molecule 2
Uniprot ID
Q8N3J6
功能
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
化学信息
分子量Theoretical: 45 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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