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Anti-CA9/Carbonic Anhydrase IX Antibody (4F130)
还可以产品编号 TMAY-00272
Anti-CA9/Carbonic Anhydrase IX Antibody (4F130) 是一种 Rabbit 抗体，靶向 CA9/Carbonic Anhydrase IX。Anti-CA9/Carbonic Anhydrase IX Antibody (4F130) 可用于 FCM。
Anti-CA9/Carbonic Anhydrase IX Antibody (4F130)
Anti-CA9/Carbonic Anhydrase IX Antibody (4F130)
还可以产品编号 TMAY-00272
Anti-CA9/Carbonic Anhydrase IX Antibody (4F130) 是一种 Rabbit 抗体，靶向 CA9/Carbonic Anhydrase IX。Anti-CA9/Carbonic Anhydrase IX Antibody (4F130) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CA9/Carbonic Anhydrase IX Antibody (4F130) is a Rabbit antibody targeting CA9/Carbonic Anhydrase IX. Anti-CA9/Carbonic Anhydrase IX Antibody (4F130) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4F130 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CAIX expression on Hela cells. Cells were stained with purified anti-Human CAIX, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Carbonic Anhydrase IX/CA9 (rh Carbonic Anhydrase IX/CA9; TMPY-00690; NP_001207.2; Met1-Asp414). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | FITC/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human Carbonic Anhydrase IX/CA9 Protein (TMPY-00690) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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