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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-C3IP1 Polyclonal Antibody

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货号 TMAB-03425

Anti-C3IP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 C3IP1。Anti-C3IP1 Polyclonal Antibody 可用于 WB。

Anti-C3IP1 Polyclonal Antibody

Anti-C3IP1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-03425

Anti-C3IP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 C3IP1。Anti-C3IP1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-C3IP1 Polyclonal Antibody is a Rabbit antibody targeting C3IP1. Anti-C3IP1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Horse,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasmic vesicle, COPII-coated vesicle.
组织特异性Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景KLHL12 is a 568 amino acid protein that is a component of an ubiquitin-protein E3 ligase complex, which includes at least CUL-3. KLHL12 is a substrate-specific adapter for the complex, which negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of Dvl-3. KLHL12 contains six Kelch repeats and one BTB (POZ) domain, which is required for interaction with CUL-3. KLHL12 has highest expression in testis, with lower levels found in the submandibular salivary gland. The gene that encodes KLHL12 maps to human chromosome 1q32.1
抗原信息
免疫原
KLH conjugated synthetic peptide: human C3IP1
抗原种属
Human
基因名称
KLHL12
基因ID
59349
蛋白名称
Kelch-like protein 12
Uniprot ID
Q53G59
功能
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
化学信息
分子量Theoretical: 63 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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