Anti-BubR1 Antibody (8W600) is a Rabbit antibody targeting BubR1. Anti-BubR1 Antibody (8W600) can be used in WB,IHC-P,IHC-Fr,IP,FCM,IF.

IgG

8W600

Human,Mouse,Rat

WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IP: 1:20-50; FCM: 1:50-100; IF: 1:50-200

Monoclonal

A synthesized peptide: human BUB1B

Human

BUB1B

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.