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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-BRAF35 Polyclonal Antibody

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货号 TMAB-03202

Anti-BRAF35 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BRAF35。Anti-BRAF35 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-BRAF35 Polyclonal Antibody

Anti-BRAF35 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-03202

Anti-BRAF35 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BRAF35。Anti-BRAF35 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-BRAF35 Polyclonal Antibody is a Rabbit antibody targeting BRAF35. Anti-BRAF35 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Cow)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Chromosome. Localized to condensed chromosomes in mitosis in conjunction with BRCA2.
组织特异性Ubiquitously expressed in adult tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The breast cancer susceptibility gene (BRCA1) localizes to chromosome 17q. Mutations within this gene account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast cancer, but unlike BRCA1, BRCA2 does not confer a substantially elevated risk of ovarian cancer. The BRCA2-Associated Factor 35 (BRAF35) protein forms a complex with BRCA2, which associates with condensed chromatin during histone H3 phosphorylation. BRAF35 expression levels are highest in proliferating tissues and parallel BRCA2 expression patterns. The structure of BRAF35 includes a kinesin-like coiled coil domain and a nonspecific DNA binding HMG domain. The chromatin localization of BRAF35 and antibody microinjection studies indicate a role for the BRAF35/BRCA2 complex in cell cycle regulation.
抗原信息
免疫原
KLH conjugated synthetic peptide: human BRAF35
抗原种属
Human
基因名称
HMG20B
基因ID
10362
蛋白名称
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
Uniprot ID
Q9P0W2
功能
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
化学信息
分子量Theoretical: 36 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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