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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-BLNK Antibody (2Y89)

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货号 TMAB-03157

Anti-BLNK Antibody (2Y89) 是一种 Rabbit 抗体，靶向 BLNK。Anti-BLNK Antibody (2Y89) 可用于 WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF。

Anti-BLNK Antibody (2Y89)

Anti-BLNK Antibody (2Y89)

一键复制产品信息
Rating icon 还可以
货号 TMAB-03157

Anti-BLNK Antibody (2Y89) 是一种 Rabbit 抗体，靶向 BLNK。Anti-BLNK Antibody (2Y89) 可用于 WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

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产品描述
Anti-BLNK Antibody (2Y89) is a Rabbit antibody targeting BLNK. Anti-BLNK Antibody (2Y89) can be used in WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF.
Ig Type
IgG
克隆号
2Y89
反应种属
Human,Mouse (predicted:Rat)
应用WBIHC-PIHC-FrIFFCMICC/IF
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; FCM: 1:50-100; ICC/IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction.
组织特异性Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes.
抗原信息
免疫原
A synthesized peptide: human BLNK
抗原种属
Human
基因名称
BLNK
基因ID
29760
蛋白名称
B-cell linker protein
Uniprot ID
Q8WV28
功能
Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Plays an important role in BCR-induced B-cell apoptosis.
化学信息
分子量Theoretical: 50 kDa. Actual: 70 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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