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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-BIG1 Polyclonal Antibody

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货号 TMAB-03142

Anti-BIG1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BIG1。Anti-BIG1 Polyclonal Antibody 可用于 WB。

Anti-BIG1 Polyclonal Antibody

Anti-BIG1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-03142

Anti-BIG1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BIG1。Anti-BIG1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-BIG1 Polyclonal Antibody is a Rabbit antibody targeting BIG1. Anti-BIG1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Chicken,Dog,Pig,Cow,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network (By similarity). Nucleus. Nucleus, nucleolus. Nucleus matrix. Membrane. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.
组织特异性Expressed in placenta, lung, heart, brain, kidney and pancreas.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.
抗原信息
免疫原
KLH conjugated synthetic peptide: human BIG1/ARFGEF1
抗原种属
Human
基因名称
ARFGEF1
基因ID
10565
蛋白名称
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Uniprot ID
Q9Y6D6
功能
BIG1 is a brefeldin A-inhibited guanine nucleotide exchange protein (GEP) that activates ADP-ribosylation factor (ARF) GTPases and functions in vesicle formation from Golgi membranes.
化学信息
分子量Theoretical: 209 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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