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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-BBS5 Polyclonal Antibody

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货号 TMAB-03035

Anti-BBS5 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BBS5。Anti-BBS5 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-BBS5 Polyclonal Antibody

Anti-BBS5 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-03035

Anti-BBS5 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BBS5。Anti-BBS5 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-BBS5 Polyclonal Antibody is a Rabbit antibody targeting BBS5. Anti-BBS5 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. Other associated clinical findings in BBS patients include diabetes, hypertension and congenital heart defects. BBS is a heterogeneous disorder; BBS genes map to eight genetic loci and encode eight proteins, BBS1-BBS8. Five BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS5 localizes to ciliary basal bodies and is a member of the basal body/flagellar proteome. It plays a role in flagellar and basal body assembly and function. A mutation or loss of BBS5 may be correlated with photoreceptor degeneration
抗原信息
免疫原
KLH conjugated synthetic peptide: human BBS5
抗原种属
Human
基因名称
BBS5
基因ID
129880
蛋白名称
Bardet-Biedl syndrome 5 protein
Uniprot ID
Q8N3I7
功能
The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.
化学信息
分子量Theoretical: 38 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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