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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-B7H4 Polyclonal Antibody 2

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货号 TMAB-03000

Anti-B7H4 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 B7H4。Anti-B7H4 Polyclonal Antibody 2 可用于 WB。

Anti-B7H4 Polyclonal Antibody 2

Anti-B7H4 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-03000

Anti-B7H4 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 B7H4。Anti-B7H4 Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-B7H4 Polyclonal Antibody 2 is a Rabbit antibody targeting B7H4. Anti-B7H4 Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Dog,Cow,Horse,Rabbit,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell surface. A soluble form has also been detected.
组织特异性Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景B7-H4 protein is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell responses. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.
抗原信息
免疫原
KLH conjugated synthetic peptide: human B7H4
抗原种属
Human
基因名称
VTCN1
基因ID
79679
蛋白名称
V-set domain-containing T-cell activation inhibitor 1
Uniprot ID
Q7Z7D3
功能
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
化学信息
分子量Theoretical: 28 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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