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Anti-B7-H3 Antibody-PE (7G630)
还可以产品编号 TMAY-01732P
Anti-B7-H3 Antibody-PE (7G630) 是一种 PE-conjugated Mouse 抗体，靶向 B7-H3。Anti-B7-H3 Antibody-PE (7G630) 可用于 FCM。
Anti-B7-H3 Antibody-PE (7G630)
Anti-B7-H3 Antibody-PE (7G630)
还可以产品编号 TMAY-01732P
Anti-B7-H3 Antibody-PE (7G630) 是一种 PE-conjugated Mouse 抗体，靶向 B7-H3。Anti-B7-H3 Antibody-PE (7G630) 可用于 FCM。
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| 产品描述 | Anti-B7-H3 Antibody-PE (7G630) is a PE-conjugated Mouse antibody targeting B7-H3. Anti-B7-H3 Antibody-PE (7G630) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 7G630 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of anti-B7H3 (CD276) reactivity on PC-3 cells. |
| 应用 | FCM |
| 推荐剂量 | 2 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human B7-H3 / CD276 (rh B7-H3 / CD276; TMPY-02031; Q5ZPR3-1; Met 1-Thr 461) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated/APC/FITC/HRP |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human B7-H3 / CD276 protein (TMPY-02031) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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