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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-ATXN10 Polyclonal Antibody

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货号 TMAB-02967

Anti-ATXN10 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ATXN10。Anti-ATXN10 Polyclonal Antibody 可用于 WB,FCM。

Anti-ATXN10 Polyclonal Antibody

Anti-ATXN10 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-02967

Anti-ATXN10 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ATXN10。Anti-ATXN10 Polyclonal Antibody 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-ATXN10 Polyclonal Antibody is a Rabbit antibody targeting ATXN10. Anti-ATXN10 Polyclonal Antibody can be used in WB,FCM.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Horse,Sheep)
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 2μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, perinuclear region.
组织特异性Expressed in the central nervous system.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss. SCA is caused by the expansion of a translated CAG repeat, encoding a polyglutamine tract in SCA gene products, known as ataxins. The ataxin proteins are ubiquitously expressed in nervous tissue, but are primarily detected in cerebellum, brain stem and spinal cord in the central nervous system. Ataxin-10 is a cytoplasmic protein that belongs to the family of armadillo repeat proteins. A loss of ataxin-10 in primary neuronal cells causes increased apoptosis of cerebellar neurons. Ataxin-10 interacts with p110, an O-Linked beta-N-acetylglucosamine transferase, and may be important in the regulation of intracellular glycosylation levels and homeostasis in the brain. Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that causes cerebellar ataxia and seizures. SCA10 is caused by an expansion of an ATTCT pentanucleotide repeat in intron 9 of the ataxin-10 gene.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ATXN10/SCA10
抗原种属
Human
基因名称
ATXN10
基因ID
25814
蛋白名称
Ataxin-10
Uniprot ID
Q9UBB4
功能
Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
化学信息
分子量Theoretical: 53 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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