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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-ATP6V0A1 Polyclonal Antibody

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货号 TMAB-02955

Anti-ATP6V0A1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ATP6V0A1。Anti-ATP6V0A1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-ATP6V0A1 Polyclonal Antibody

Anti-ATP6V0A1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-02955

Anti-ATP6V0A1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ATP6V0A1。Anti-ATP6V0A1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-ATP6V0A1 Polyclonal Antibody is a Rabbit antibody targeting ATP6V0A1. Anti-ATP6V0A1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The subunit of the vacuolar proton pump is a V-ATPase that has two different isoforms. The type I isoform contains an 18-base pair insert and is expressed in brain, whereas the truncated type II isoform is more widely expressed, including lung, kidney and spleen. The subunit of the vacuolar proton pump is located in clathrin-coated vesicles and is also found in osteoclasts. It consists of two fundamental domains, a hydrophilic amino-terminus, which has greater than 30% charged residues, and a hydrophobic carboxy terminus, which contains at least six transmembrane regions. The proton pump functions in coupling ATP hydrolysis by the cytoplasmic subunits to proton translocation by the intramembranous components of the pump. The inactivation of the osteoclast-specific vacuolar proton ATPase subunit is responsible for the lack of the enzyme in the apical membranes of osteoclast cells in osteosclerotic mutant mice, thus preventing the resorption function of these cells and leading to the osteopetrotic phenotype. The subunit, which co-localizes with the late endosomal marker Rab7 on vacuolar membranes, is essential for vacuole formation by selective swelling of late endosomes.
抗原信息
免疫原
KLH conjugated synthetic peptide: human V-ATPase A1
抗原种属
Human
基因名称
ATP6V0A1
基因ID
535
蛋白名称
V-type proton ATPase 116 kDa subunit a1
Uniprot ID
Q93050
功能
Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).
化学信息
分子量Theoretical: 96 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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