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Anti-ATF1 Antibody (4G420)

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货号 TMAB-02896

Anti-ATF1 Antibody (4G420) 是一种 Rabbit 抗体，靶向 ATF1。Anti-ATF1 Antibody (4G420) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-ATF1 Antibody (4G420)

Anti-ATF1 Antibody (4G420)

一键复制产品信息
Rating icon 还可以
货号 TMAB-02896

Anti-ATF1 Antibody (4G420) 是一种 Rabbit 抗体，靶向 ATF1。Anti-ATF1 Antibody (4G420) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-ATF1 Antibody (4G420) is a Rabbit antibody targeting ATF1. Anti-ATF1 Antibody (4G420) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
4G420
反应种属
Human,Rat,Mouse
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:1000-5000; IHC-P: 1:100-1000; IHC-Fr: 1:100-1000; IF: 1:100-1000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
抗原信息
免疫原
KLH conjugated synthetic peptide: human ATF1
抗原种属
Human
基因名称
ATF1
基因ID
466
蛋白名称
Cyclic AMP-dependent transcription factor ATF-1
Uniprot ID
P18846
功能
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
化学信息
分子量Theoretical: 29 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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