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Anti-AT2R2 Polyclonal Antibody

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货号 TMAB-00156

别名 Type 2 angiotensin II receptor, MRX88, MRX 88, ATGR2, ATGR 2, AT2R2, AT2, AT 2, Angiotensin receptor 2, Angiotensin II type-2 receptor, Angiotensin II Type 2, angiotensin II receptor type 2, AGTR2, AGTR 2

Anti-AT2R2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 AT2R2。Anti-AT2R2 Polyclonal Antibody 可用于 WB。

Anti-AT2R2 Polyclonal Antibody

Anti-AT2R2 Polyclonal Antibody

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货号 TMAB-00156 别名 Type 2 angiotensin II receptor, MRX88, MRX 88, ATGR2, ATGR 2, AT2R2, AT2, AT 2, Angiotensin receptor 2, Angiotensin II type-2 receptor, Angiotensin II Type 2, angiotensin II receptor type 2, AGTR2, AGTR 2

Anti-AT2R2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 AT2R2。Anti-AT2R2 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-AT2R2 Polyclonal Antibody is a Rabbit antibody targeting AT2R2. Anti-AT2R2 Polyclonal Antibody can be used in WB.
别名Type 2 angiotensin II receptor, MRX88, MRX 88, ATGR2, ATGR 2, AT2R2, AT2, AT 2, Angiotensin receptor 2, Angiotensin II type-2 receptor, Angiotensin II Type 2, angiotensin II receptor type 2, AGTR2, AGTR 2
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Pig,Horse,Sheep)
验证活性
Sample:
Lane 1: Mouse Uterus tissue lysates
Lane 2: Mouse Liver tissue lysates
Lane 3: Rat Uterus tissue lysates
Primary: Anti-AT2R2 (TMAB-00156) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kDa
Observed band size: 50 kDa
verifiedActivity
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane.
组织特异性In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.
抗原信息
免疫原
KLH conjugated synthetic peptide: human angiotensin II receptor type 2
抗原种属
Human
基因名称
AGTR2
基因ID
186
蛋白名称
Type-2 angiotensin II receptor
Uniprot ID
P50052
研究领域
Apoptosis,Blood Pressure regulation,GPCR,PLC
功能
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
化学信息
分子量Theoretical: 41 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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