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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-ASPP2 Polyclonal Antibody

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货号 TMAB-02877

Anti-ASPP2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ASPP2。Anti-ASPP2 Polyclonal Antibody 可用于 WB,ICC/IF。

Anti-ASPP2 Polyclonal Antibody

Anti-ASPP2 Polyclonal Antibody

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货号 TMAB-02877

Anti-ASPP2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ASPP2。Anti-ASPP2 Polyclonal Antibody 可用于 WB,ICC/IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-ASPP2 Polyclonal Antibody is a Rabbit antibody targeting ASPP2. Anti-ASPP2 Polyclonal Antibody can be used in WB,ICC/IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Chicken)
应用WBICC/IF
推荐剂量
WB: 1:500-2000; ICC/IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
组织特异性Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human ASPP2
抗原种属
Human
基因名称
TP53BP2
基因ID
7159
蛋白名称
Apoptosis-stimulating of p53 protein 2
Uniprot ID
Q13625
功能
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
化学信息
分子量Theoretical: 124 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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