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Anti-ASC/TMS1 Antibody (2P286)

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货号 TMAB-02862

Anti-ASC/TMS1 Antibody (2P286) 是一种 Rabbit 抗体，靶向 ASC/TMS1。Anti-ASC/TMS1 Antibody (2P286) 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-ASC/TMS1 Antibody (2P286)

Anti-ASC/TMS1 Antibody (2P286)

一键复制产品信息
Rating icon 还可以
货号 TMAB-02862

Anti-ASC/TMS1 Antibody (2P286) 是一种 Rabbit 抗体，靶向 ASC/TMS1。Anti-ASC/TMS1 Antibody (2P286) 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-ASC/TMS1 Antibody (2P286) is a Rabbit antibody targeting ASC/TMS1. Anti-ASC/TMS1 Antibody (2P286) can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
2P286
反应种属
Human
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.
组织特异性Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Functions as a key mediator in apoptosis and inflammation.Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner.Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ASC
抗原种属
Human
基因名称
PYCARD
基因ID
29108
蛋白名称
Apoptosis-associated speck-like protein containing a CARD
Uniprot ID
Q9ULZ3
功能
Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
化学信息
分子量Theoretical: 22 kDa. Actual: 22 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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