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Anti-ARH Polyclonal Antibody

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货号 TMAB-02822

Anti-ARH Polyclonal Antibody 是一种 Rabbit 抗体,靶向 ARH。Anti-ARH Polyclonal Antibody 可用于 WB。

Anti-ARH Polyclonal Antibody

Anti-ARH Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-02822

Anti-ARH Polyclonal Antibody 是一种 Rabbit 抗体,靶向 ARH。Anti-ARH Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
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产品介绍


生物活性
产品描述
Anti-ARH Polyclonal Antibody is a Rabbit antibody targeting ARH. Anti-ARH Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ARH/LDL receptor adaptor protein
抗原种属
Human
基因名称
LDLRAP1
基因ID
蛋白名称
Low density lipoprotein receptor adapter protein 1
Uniprot ID
功能
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
化学信息
分子量Theoretical: 34 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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