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Anti-ARH Polyclonal Antibody 是一种 Rabbit 抗体,靶向 ARH。Anti-ARH Polyclonal Antibody 可用于 WB。
Anti-ARH Polyclonal Antibody 是一种 Rabbit 抗体,靶向 ARH。Anti-ARH Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 |
| 产品描述 | Anti-ARH Polyclonal Antibody is a Rabbit antibody targeting ARH. Anti-ARH Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| 反应种属 | Mouse,Rat |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. |
| 免疫原 | KLH conjugated synthetic peptide: human ARH/LDL receptor adaptor protein |
| 抗原种属 | Human |
| 基因名称 | LDLRAP1 |
| 基因ID | |
| 蛋白名称 | Low density lipoprotein receptor adapter protein 1 |
| Uniprot ID | |
| 功能 | Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. |
| 分子量 | Theoretical: 34 kDa. |
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
| 存储 | store at low temperature | -20°C for 1 year |