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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-APPBP1 Polyclonal Antibody

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货号 TMAB-02783

Anti-APPBP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 APPBP1。Anti-APPBP1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-APPBP1 Polyclonal Antibody

Anti-APPBP1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-02783

Anti-APPBP1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 APPBP1。Anti-APPBP1 Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-APPBP1 Polyclonal Antibody is a Rabbit antibody targeting APPBP1. Anti-APPBP1 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Dog,Pig,Horse,Rabbit)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Colocalizes with APP in lipid rafts.
组织特异性Ubiquitous in fetal tissues. Expressed throughout the adult brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景APPBP1 is a member of the ubiquitin-activating E1 family. In fetal tissues APPBP1 is widely expressed and in adult tissues it is expressed throughout the brain. APPBP1 is a cell membrane associated protein and functions as the regulatory subunit in a heterodimer with UBA3. The APPBP1/UBA3 complex binds to and activates NEDD8, a ubiquitin-like protein involved in signal transduction, cell proliferation and development. This suggests that APPBP1 affects a variety of cellular functions. In addition, APPBP1 is essential for cell cycle progression through the S/M checkpoint. More specifically, it inhibits the entry into S phase and promotes entry into M phase.
抗原信息
免疫原
KLH conjugated synthetic peptide: human APPBP1
抗原种属
Human
基因名称
NAE1
基因ID
8883
蛋白名称
NEDD8-activating enzyme E1 regulatory subunit
Uniprot ID
Q13564
功能
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
化学信息
分子量Theoretical: 60 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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