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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-APOBEC3C Polyclonal Antibody

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货号 TMAB-02760

Anti-APOBEC3C Polyclonal Antibody 是一种 Rabbit 抗体，靶向 APOBEC3C。Anti-APOBEC3C Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

Anti-APOBEC3C Polyclonal Antibody

Anti-APOBEC3C Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-02760

Anti-APOBEC3C Polyclonal Antibody 是一种 Rabbit 抗体，靶向 APOBEC3C。Anti-APOBEC3C Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-APOBEC3C Polyclonal Antibody is a Rabbit antibody targeting APOBEC3C. Anti-APOBEC3C Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
反应种属
Human
应用IHC-PIHC-FrICC/IFIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm.
组织特异性Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
抗原信息
免疫原
KLH conjugated synthetic peptide: human APOBEC3C
抗原种属
Human
基因名称
APOBEC3C
基因ID
27350
蛋白名称
DNA dC->dU-editing enzyme APOBEC-3C
Uniprot ID
Q9NRW3
功能
Host cellular restriction factor that may have antiviral activities against exogenous and endogenous viruses, as well as retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
化学信息
分子量Theoretical: 23 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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