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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-APEX2 Polyclonal Antibody

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货号 TMAB-02739

Anti-APEX2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 APEX2。Anti-APEX2 Polyclonal Antibody 可用于 WB。

Anti-APEX2 Polyclonal Antibody

Anti-APEX2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-02739

Anti-APEX2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 APEX2。Anti-APEX2 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
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产品介绍

生物活性
产品描述
Anti-APEX2 Polyclonal Antibody is a Rabbit antibody targeting APEX2. Anti-APEX2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse,Rat
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Mitochondrion (Probable). Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
组织特异性Highly expressed in brain and kidney. Weakly expressed in the fetal brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
抗原信息
免疫原
KLH conjugated synthetic peptide: human APEX2
抗原种属
Human
基因名称
APEX2
基因ID
27301
蛋白名称
DNA-(apurinic or apyrimidinic site) endonuclease 2
Uniprot ID
Q9UBZ4
功能
Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
化学信息
分子量Theoretical: 57 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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