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Anti-APC Antibody (4C476)

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货号 TMAB-02731

Anti-APC Antibody (4C476) 是一种 Rabbit 抗体，靶向 APC。Anti-APC Antibody (4C476) 可用于 WB,IHC-P,IHC-Fr,IF,IP。

Anti-APC Antibody (4C476)

Anti-APC Antibody (4C476)

一键复制产品信息
Rating icon 还可以
货号 TMAB-02731

Anti-APC Antibody (4C476) 是一种 Rabbit 抗体，靶向 APC。Anti-APC Antibody (4C476) 可用于 WB,IHC-P,IHC-Fr,IF,IP。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-APC Antibody (4C476) is a Rabbit antibody targeting APC. Anti-APC Antibody (4C476) can be used in WB,IHC-P,IHC-Fr,IF,IP.
Ig Type
IgG
克隆号
4C476
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrIFIP
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; IP: 1:20-50
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Note=Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
组织特异性Expressed in a variety of tissues.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Associates with both microtubules and actin filaments, components of the cytoskeleton.
抗原信息
免疫原
A synthesized peptide: human APC
抗原种属
Human
基因名称
APC
基因ID
324
蛋白名称
Adenomatous polyposis coli protein
Uniprot ID
P25054
功能
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
化学信息
分子量Theoretical: 312 kDa. Actual: 160 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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