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Anti-APAF1 (CT) Polyclonal Antibody

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货号 TMAB-02727

Anti-APAF1 (CT) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 APAF1 (CT)。Anti-APAF1 (CT) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

Anti-APAF1 (CT) Polyclonal Antibody

Anti-APAF1 (CT) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-02727

Anti-APAF1 (CT) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 APAF1 (CT)。Anti-APAF1 (CT) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-APAF1 (CT) Polyclonal Antibody is a Rabbit antibody targeting APAF1 (CT). Anti-APAF1 (CT) Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
反应种属
Human,Rat (predicted:Mouse,Dog,Horse,Danio rerio)
应用IHC-PIHC-FrICC/IFIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain(NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated synthetic peptide: human Apaf-1
抗原种属
Human
基因名称
APAF1
基因ID
317
蛋白名称
Apoptotic protease-activating factor 1
Uniprot ID
O14727
功能
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
化学信息
分子量Theoretical: 137 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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