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Anti-AIF Antibody (3I201)

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货号 TMAB-02393

Anti-AIF Antibody (3I201) 是一种 Rabbit 抗体，靶向 AIF。Anti-AIF Antibody (3I201) 可用于 WB,IHC-P,IF,IHC-Fr。

Anti-AIF Antibody (3I201)

Anti-AIF Antibody (3I201)

一键复制产品信息
Rating icon 还可以
货号 TMAB-02393

Anti-AIF Antibody (3I201) 是一种 Rabbit 抗体，靶向 AIF。Anti-AIF Antibody (3I201) 可用于 WB,IHC-P,IF,IHC-Fr。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

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产品描述
Anti-AIF Antibody (3I201) is a Rabbit antibody targeting AIF. Anti-AIF Antibody (3I201) can be used in WB,IHC-P,IF,IHC-Fr.
Ig Type
IgG
克隆号
3I201
反应种属
Human,Mouse,Rat
应用WBIHC-PIFIHC-Fr
推荐剂量
WB: 1:1000-5000; IHC-P: 1:200-800; IF: 1:200-800; IHC-Fr: 1:200-800
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.
组织特异性Isoform 5 is frequently down-regulated in human cancers.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液pH7.4, 150mM NaCl, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010].
抗原信息
免疫原
A synthesized peptide: human AIF
抗原种属
Human
基因名称
AIFM1
基因ID
9131
蛋白名称
Apoptosis-inducing factor 1, mitochondrial
Uniprot ID
O95831
功能
Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
化学信息
分子量Theoretical: 67 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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