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Anti-ADIPOR1 Polyclonal Antibody
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还可以产品编号 TMAB-00064
别名 TESBP1A, Progestin and adipoQ receptor family member I, Progestin and adipoQ receptor family member 1, PAQR1, ADIPOR1, Adiponectin receptor protein 1
Anti-ADIPOR1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ADIPOR1。Anti-ADIPOR1 Polyclonal Antibody 可用于 IF,IHC-Fr,WB。
Anti-ADIPOR1 Polyclonal Antibody
Anti-ADIPOR1 Polyclonal Antibody
一键复制产品信息 还可以产品编号 TMAB-00064 别名 TESBP1A, Progestin and adipoQ receptor family member I, Progestin and adipoQ receptor family member 1, PAQR1, ADIPOR1, Adiponectin receptor protein 1
Anti-ADIPOR1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ADIPOR1。Anti-ADIPOR1 Polyclonal Antibody 可用于 IF,IHC-Fr,WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,175 | 5日内发货 | |
| 100 μL | ¥ 1,960 | 5日内发货 | |
| 200 μL | ¥ 2,785 | 5日内发货 |
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| 产品描述 | Anti-ADIPOR1 Polyclonal Antibody is a Rabbit antibody targeting ADIPOR1. Anti-ADIPOR1 Polyclonal Antibody can be used in IF,IHC-Fr,WB. |
| 别名 | TESBP1A, Progestin and adipoQ receptor family member I, Progestin and adipoQ receptor family member 1, PAQR1, ADIPOR1, Adiponectin receptor protein 1 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat (predicted:Chicken,Dog,Rabbit) |
| 验证活性 | 1. Sample: Muscle (Mouse) Lysate at 40 μg Primary: Anti-Adiponectin Receptor 1 (TMAB-00064) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kDa Observed band size: 42 kDa 2. Sample: Lane 1: Mouse Muscle tissue lysates Lane 2: Mouse Breast tissue lysates Lane 3: Mouse Heart tissue lysates Lane 4: Rat Muscle tissue lysates Lane 5: Rat Heart tissue lysates Primary: Anti-Adiponectin Receptor 1 (TMAB-00064) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kDa Observed band size: 42 kDa   |
| 应用 | IFIHC-FrWB |
| 推荐剂量 | WB: 1:500-2000; IHC-Fr: 1:100-500; IF: 1:100-500 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles. |
| 组织特异性 | Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR- . Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. |
| 免疫原 | KLH conjugated synthetic peptide: human Adiponectin Receptor 1 |
| 抗原种属 | Human |
| 基因名称 | ADIPOR1 |
| 基因ID | |
| 蛋白名称 | Adiponectin receptor protein 1 |
| Uniprot ID | |
| 研究领域 | Acrp,Hormones |
| 功能 | Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. |
| 分子量 | Theoretical: 42 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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