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Anti-ACOX1 Antibody (2L405) 是一种 Rabbit 抗体,靶向 ACOX1。Anti-ACOX1 Antibody (2L405) 可用于 IHC-P。
Anti-ACOX1 Antibody (2L405) 是一种 Rabbit 抗体,靶向 ACOX1。Anti-ACOX1 Antibody (2L405) 可用于 IHC-P。
产品描述 | Anti-ACOX1 Antibody (2L405) is a Rabbit antibody targeting ACOX1. Anti-ACOX1 Antibody (2L405) can be used in IHC-P. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 2L405 |
交叉反应 | Human |
验证活性 | 1. Immunochemical staining of human ACOX1 in human liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte. 2. Immunochemical staining of human ACOX1 in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to proximal tubule. |
应用 | IHC-P |
推荐剂量 | IHC-P: 1:100-1:500 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human ACOX1 / AOX (rh ACOX1 / AOX; TMPY-02481; AAH08767.1; Met1-Leu660). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a protein of 661-amino acids, including the carboxyl-terminal sequence(Ser-Lys-Leu) known as a minimal peroxisome-targeting signal. Human ACOX1/AOX, the first and rate-limiting enzyme of the peroxisomal β-oxidation pathway, has two isoforms including ACOX1a and ACOX1b, transcribed from a single gene. The human ACOX1b isoform is more effective than the ACOX1a isoform in reversing the Acox1 null phenotype in the mouse partly because of the Substrate utilization differences. |
偶联 | Unconjugated |
免疫原 | Recombinant Human ACOX1 / AOX protein (TMPY-02481) |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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