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Anti-ACOX1 Antibody (2L405)

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产品编号 TMAY-01805

Anti-ACOX1 Antibody (2L405) 是一种 Rabbit 抗体,靶向 ACOX1。Anti-ACOX1 Antibody (2L405) 可用于 IHC-P。

Anti-ACOX1 Antibody (2L405)

Anti-ACOX1 Antibody (2L405)

Rating icon 还可以
产品编号 TMAY-01805

Anti-ACOX1 Antibody (2L405) 是一种 Rabbit 抗体,靶向 ACOX1。Anti-ACOX1 Antibody (2L405) 可用于 IHC-P。

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产品介绍

生物活性
产品描述
Anti-ACOX1 Antibody (2L405) is a Rabbit antibody targeting ACOX1. Anti-ACOX1 Antibody (2L405) can be used in IHC-P.
Ig Type
Monoclonal Rabbit IgG
克隆号
2L405
交叉反应
Human
验证活性
1. Immunochemical staining of human ACOX1 in human liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.

2. Immunochemical staining of human ACOX1 in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to proximal tubule.
应用
IHC-P
推荐剂量
IHC-P: 1:100-1:500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human ACOX1 / AOX (rh ACOX1 / AOX; TMPY-02481; AAH08767.1; Met1-Leu660).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a protein of 661-amino acids, including the carboxyl-terminal sequence(Ser-Lys-Leu) known as a minimal peroxisome-targeting signal. Human ACOX1/AOX, the first and rate-limiting enzyme of the peroxisomal β-oxidation pathway, has two isoforms including ACOX1a and ACOX1b, transcribed from a single gene. The human ACOX1b isoform is more effective than the ACOX1a isoform in reversing the Acox1 null phenotype in the mouse partly because of the Substrate utilization differences.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Human ACOX1 / AOX protein (TMPY-02481)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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