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Anti-15-PGDH Antibody (5R318)
还可以产品编号 TMAY-03342
Anti-15-PGDH Antibody (5R318) 是一种 Rabbit 抗体，靶向 15-PGDH。Anti-15-PGDH Antibody (5R318) 可用于 WB,IP。
Anti-15-PGDH Antibody (5R318)
Anti-15-PGDH Antibody (5R318)
还可以产品编号 TMAY-03342
Anti-15-PGDH Antibody (5R318) 是一种 Rabbit 抗体，靶向 15-PGDH。Anti-15-PGDH Antibody (5R318) 可用于 WB,IP。
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偶联与修饰
抗原信息
| 产品描述 | Anti-15-PGDH Antibody (5R318) is a Rabbit antibody targeting 15-PGDH. Anti-15-PGDH Antibody (5R318) can be used in WB,IP. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5R318 |
| 交叉反应 | Mouse |
| 验证活性 | 1. Anti-HPGD rabbit monoclonal antibody at 1:500 dilution. -Lane A: LOVO Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:29 kDa. -Observed band size:27 kDa. 2. Mouse HPGD was immunoprecipitated using: -Lane A:0.5 mg Caco-2 Whole Cell Lysate. -2 µL anti-Mouse HPGD rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose. -Primary antibody: -Anti-Mouse HPGD rabbit monoclonal antibody, at 1:200 dilution. -Secondary antibody: -Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution. -Developed using the odyssey technique. -Performed under reducing conditions. -Predicted band size: 29 kDa. -Observed band size: 29 kDa |
| 应用 | WB,IP |
| 推荐剂量 | WB: 1:500-1:2000; IP: 1-4 μL/mg of lysate |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse HPGD / 15-PGDH (rM HPGD / 15-PGDH; TMPY-02273; Q8VCC1; Met1-Ser269). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse HPGD / 15-PGDH protein (TMPY-02273) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
SCI 文献
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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