Name: A-317491 sodium
Brand: TargetMol
SKU: TQ0002L
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

100 mg

待询

500 mg

待询

生物活性

产品描述	A-317491 sodium is a potent and selective antagonist of the P2X3 and P2X2/3 purinergic receptors, with a reported >1000-fold selectivity over other P2X receptor subtypes. The compound acts by blocking ATP-gated ion channels expressed on sensory neurons, and in rodent models, acute administration at 100 μmol/kg is used to evaluate peripheral nociceptive signaling. This antagonist is widely employed in preclinical research to investigate the role of P2X3 receptor activation in pain pathways and sensory neuron excitability.
体内活性	A-317491 sodium 是一种用于科研的P2X3受体拮抗剂。在癌症诱导骨痛小鼠模型中，慢性皮下给药（30 μmol/kg，每日两次）可在早期阶段短暂减轻疼痛相关行为，但对晚期进展阶段无效。急性皮下给药（100 μmol/kg）在进展阶段同样未观察到效果。该产品适用于研究P2X3受体在疼痛传导中的早期作用机制，尤其适合探索慢性疼痛模型中的时间依赖性药效差异。给药方式为皮下注射，需注意早期干预的时间窗口。
别名	A-317491, A317491, A 317491

化学信息

分子量	631.12
分子式	C₃₃H₂₄NNa₃O₈
Smiles	O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C([O-])=O)C=C1C([O-])=O)[O-].[Na+].[Na+].[Na+]
密度	no data available

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

A-317491 sodium