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Prifuroline

Prifuroline

产品编号 T12538   CAS 70833-07-7

Prifuroline is an agent of antiarrhythmic.

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Prifuroline Chemical Structure
Prifuroline, CAS 70833-07-7
规格 价格/CNY 货期 数量
25 mg ¥ 10,600 6-8周
50 mg ¥ 13,800 6-8周
100 mg ¥ 17,500 6-8周
千万补贴 助力科研
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产品目录号及名称: Prifuroline (T12538)
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参考文献
产品描述 Prifuroline is an agent of antiarrhythmic.
体内活性 Prifuroline dose-dependently antagonizes the arrhythmogenic action of aconitine in rats, when administered either intravenously (5, 10 or 20 mg/kg) or intraduodenally (10, 20 or 50 mg/kg);?it exhibits effectiveness by the digestive route at doses only twice as greater as the active i.v. doses: its intravenous anti-aconitine activity is comparable to that of disopyramide, and superior to that of quinidine;?lidocaine is inactive in this test.Prifuroline also diminishes ventricular susceptibility to electrical stimulation in open-chest rats;?its effect is comparable to that of disopyramide and amiodarone at the same dose levels;?quinidine and lidocaine are less effective.?Only prifuroline and propranolol were able to antagonize ouabain toxicity in guinea-pigs, quinidine showing only borderline activity, and disopyramide, lidocaine and verapamil being ineffective.?In a model of arrhythmias induced by anoxic stress in rats, all the tested compounds were found active, with prifuroline and disopyramide providing complete protection at high dose levels.?The arrhythmias induced in dogs by coronary artery ligation were markedly antagonized by prifuroline after doses of 5 and 10 mg/kg i.v. or 30 mg/kg intraduodenally;?the duration of its antiarrhythmic activity in this model of arrhythmias in conscious dogs was much longer after intraduodenal than after i.v. administration.?Prifuroline was also able to restore sinus rhythm in guinea-pigs after intracardiac conduction blockade with acetylcholine, although being devoid of anticholinergic activity.?It also diminishes the maximal frequency of guinea-pig atria electrically stimulated in viro (EC25 = 5 X 10(-6) g/ml).
分子量 228.29
分子式 C14H16N2O
CAS No. 70833-07-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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TargetMol Library Books参考文献

1. Benharkate M, et al. Antiarrhythmic and hemodynamic effects of prifuroline. Arzneimittelforschung. 1986 Dec;36(12):1761-7.

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Keywords

Prifuroline 70833-07-7 Others Inhibitor inhibitor inhibit

 

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