Nalidixic acid sodium salt

Name: Nalidixic acid sodium salt
Brand: TargetMol
SKU: T0909L
Price: 113 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.95%

货号 T0909LCas号 3374-05-8

别名 萘啶酮酸钠, 萘啶酮酸, Sodium nalidixate, Baktogram

Nalidixic acid sodium salt (Baktogram) 是一种喹诺酮类抗生素，对革兰氏阳性和革兰氏阴性细菌均有效。它在较低浓度下有抑菌作用，在较高浓度下有杀菌作用。它抑制 DNA 促旋酶和拓扑异构酶IV 的亚基，并可逆地阻止易感细菌中的 DNA 复制。

Nalidixic acid sodium salt

一键复制产品信息

很棒

纯度: 99.95%

货号 T0909L 别名 萘啶酮酸钠, 萘啶酮酸, Sodium nalidixate, BaktogramCas号 3374-05-8

规格	价格	库存
25 mg	¥ 113	现货
50 mg	¥ 163	现货
100 mg	¥ 247	现货
500 mg	¥ 598	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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纯度: 99.95%

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产品介绍

Nalidixic acid sodium salt AI Summary

Nalidixic acid sodium salt exhibits a broad spectrum of bioactivities. It is a potent agonist of the NFkB signaling pathway with a potency of 3.5 nM. The compound also functions as an inhibitor in various assays, showing efficacy against Influenza NS1 protein function, JMJD2E, HADH2, BAZ2B, and Bloom's syndrome helicase (BLM), with inhibition potencies ranging from 7.1 nM to 31622.8 nM. Additionally, it acts both as an inhibitor and an antagonist of the NFkB signaling pathway, exhibiting potencies of 3.5 nM and 79432.8 nM, respectively. In a Cytochrome panel assay, it has an AC50 value of 31622.78 nM. The compound has also been tested as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1), with a potency of 35481.3 nM. However, it does not inhibit cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) at MOI 0.002 after 72 hours, indicated by a negative inhibition index of -0.007949..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.
别名	萘啶酮酸钠, 萘啶酮酸, Sodium nalidixate, Baktogram

化学信息

分子量	254.22
分子式	C₁₂H₁₁N₂NaO₃
CAS No.	3374-05-8
Smiles	[Na+].CCn1cc(C([O-])=O)c(=O)c2ccc(C)nc12
密度	1.331g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: Slightly soluble

H2O: 125 mg/mL (491.7 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	3.9336 mL	19.6680 mL	39.3360 mL	196.6800 mL
5 mM	0.7867 mL	3.9336 mL	7.8672 mL	39.3360 mL
10 mM	0.3934 mL	1.9668 mL	3.9336 mL	19.6680 mL
20 mM	0.1967 mL	0.9834 mL	1.9668 mL	9.8340 mL
50 mM	0.0787 mL	0.3934 mL	0.7867 mL	3.9336 mL
100 mM	0.0393 mL	0.1967 mL	0.3934 mL	1.9668 mL