Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, has an IC50 of 0.755-1.02 nM for BTK.
产品描述 | Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, has an IC50 of 0.755-1.02 nM for BTK. |
靶点活性 | BLK:3.66-4.27 nM (IC50), BTK:0.755-1.02 nM (IC50), JAK3:5.34-4.87 μM (IC50), BMX:4.42-5.57 nM (IC50), ITK:0.187-0.198 μM (IC50), TEC:1.71-2.29 nM (IC50), Lck:5.99-6.92 nM (IC50), Src:33.8-36.3 nM (IC50) |
体外活性 | Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine- mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells[1]. |
分子量 | 1097.39 |
分子式 | C56H80N12O9S |
CAS No. | 1599432-18-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (45.56 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.9113 mL | 4.5563 mL | 9.1125 mL | 22.7813 mL |
5 mM | 0.1823 mL | 0.9113 mL | 1.8225 mL | 4.5563 mL | |
10 mM | 0.0911 mL | 0.4556 mL | 0.9113 mL | 2.2781 mL | |
20 mM | 0.0456 mL | 0.2278 mL | 0.4556 mL | 1.1391 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ibrutinib-biotin 1599432-18-4 Others Ibrutinibbiotin Ibrutinib biotin Inhibitor inhibitor inhibit