Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺 (IC50=4 nM),去甲肾上腺素 (IC50=6 nM) 和三羟色胺转运蛋白 (IC50=11 nM)的三重再摄取抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 193 | 现货 | ||
5 mg | ¥ 417 | 现货 | ||
10 mg | ¥ 671 | 现货 | ||
25 mg | ¥ 1,070 | 现货 | ||
50 mg | ¥ 1,516 | 现货 | ||
100 mg | ¥ 2,361 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 460 | 现货 |
产品描述 | Dasotraline hydrochloride (SEP-225289 hydrochloride) (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. |
靶点活性 | Norepinephrine:6nM, Dopamine:4nM, SERT:11 nM |
体内活性 | Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters because it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE[1]. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Average dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg[2]. |
别名 | SEP-225289 hydrochloride, 达索曲林盐酸盐 |
分子量 | 328.66 |
分子式 | C16H16Cl3N |
CAS No. | 675126-08-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31 mg/mL (94.32 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0427 mL | 15.2133 mL | 30.4266 mL | 76.0665 mL |
5 mM | 0.6085 mL | 3.0427 mL | 6.0853 mL | 15.2133 mL | |
10 mM | 0.3043 mL | 1.5213 mL | 3.0427 mL | 7.6066 mL | |
20 mM | 0.1521 mL | 0.7607 mL | 1.5213 mL | 3.8033 mL | |
50 mM | 0.0609 mL | 0.3043 mL | 0.6085 mL | 1.5213 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Dasotraline hydrochloride 675126-08-6 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor Serotonin Transporter Norepinephrine Dasotraline Dopamine Transporter inhibit Dasotraline Hydrochloride Inhibitor SERT SEP-225289 SEP 225289 Hydrochloride SEP225289 Hydrochloride SLC6A4 SEP 225289 5-HTT DAT SEP225289 SLC6A3 SEP-225289 hydrochloride 达索曲林盐酸盐 SEP-225289 Hydrochloride inhibitor