Apelin-13

规格	价格/CNY		数量
2 mg	￥ 478	现货
5 mg	￥ 683	现货
10 mg	￥ 1,025	现货
25 mg	￥ 2,105	现货
50 mg	￥ 3,158	现货
100 mg	￥ 4,736	现货
200 mg	￥ 7,104	现货
500 mg	￥ 10,657	现货

规格

价格/CNY

货期

数量

2 mg

￥ 478

现货

5 mg

￥ 683

现货

10 mg

￥ 1,025

现货

25 mg

￥ 2,105

现货

50 mg

￥ 3,158

现货

100 mg

￥ 4,736

现货

200 mg

￥ 7,104

现货

500 mg

￥ 10,657

现货

存储

store at low temperature,keep away from moisture　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 50 mg/mL (32.24 mM）, Sonication is recommended.

DMSO: 50 mg/mL (32.24 mM), Sonication is recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
H2O / DMSO	1 mM	0.6448 mL	3.2241 mL	6.4482 mL	16.1204 mL
	5 mM	0.129 mL	0.6448 mL	1.2896 mL	3.2241 mL
	10 mM	0.0645 mL	0.3224 mL	0.6448 mL	1.612 mL
	20 mM	0.0322 mL	0.1612 mL	0.3224 mL	0.806 mL

产品描述	Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 nM for APJ.Apelin-13 has vasodilatory and antihypertensive activity and can be used to study type 2 diabetic syndrome. Apelin-13 has vasodilatory and antihypertensive activities and can be used to study type 2 diabetes syndrome.
靶点活性	APJ:0.37 nM
体外活性	In cultured PC12 cells, the same protective effects were also observed.?Silencing Nrf2 gene with its siRNA abolished the Apelin 13's prevention of I/R-induced PC12 cell injury, oxidative stress, and inflammation.?Inhibition of AMPK by its siRNA decreased the level of Apelin 13-induced Nrf2 expression and diminished the protective effects of Apelin 13.?The interplay relationship between GSK-3β and Nrf2 was also verified with relative overexpression.?Using selective inhibitors, we further identified the upstream of AMPK/GSK-3β/Nrf2 is AR/Gα/PLC/IP3/CaMKK.
体内活性	Administered intraperitoneally at a daily dosage of 200 µg/kg for 4 weeks, Apelin-13 improves cardiac function, insulin resistance, and lipid metabolism. It significantly decreases serum levels of TNF-α and leptin, induces the expression of Apelin-12 in serum, and markedly elevates levels of GLUT4 and p-AMPKα2[2]. When delivered via intracerebroventricular injection at single dosages of 10 and 100 μM, Apelin-13 increases the spontaneous discharges in the majority of pallidal neurons[3].
细胞实验	For in vitro study, PC12 cells were used,proteases inhibitors or siRNA were used.?Protein levels were investigated by western blotting.
动物实验	In vivo, the I/R model was induced and Apelin 13 was given intracerebroventricularly 15 min before reperfusion.?The neurobehavioral scores, infarction volumes, and some cytokines in the brain were measured.

分子量	1550.83
分子式	C69H111N23O16S
CAS No.	217082-58-1

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords