4-Borono-L-phenylalanine

Name: 4-Borono-L-phenylalanine
Brand: TargetMol
SKU: T77706
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 96.45%

货号 T77706Cas号 76410-58-7

别名 L-p-Boronophenylalanine, 4-硼-L-苯基丙氨酸, (s)-2-amino-3-(4-boronophenyl)propanoic acid

4-Borono-L-phenylalanine 具有抗肿瘤活性，可用于硼中子俘获疗法治疗黑色素瘤和多形性胶质母细胞瘤的临床试验。

4-Borono-L-phenylalanine

一键复制产品信息

很棒

纯度: 96.45%

货号 T77706 别名 L-p-Boronophenylalanine, 4-硼-L-苯基丙氨酸, (s)-2-amino-3-(4-boronophenyl)propanoic acidCas号 76410-58-7

4-Borono-L-phenylalanine 具有抗肿瘤活性，可用于硼中子俘获疗法治疗黑色素瘤和多形性胶质母细胞瘤的临床试验。

规格	价格	库存	数量
100 mg	¥ 99	现货

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产品介绍

4-Borono-L-phenylalanine AI Summary

4-Borono-L-phenylalanine exhibits multifaceted bioactivity and potential therapeutic applications. It demonstrates significant uptake by F98 glioma cells, increasing cellular boron content, which may be relevant for glioma-targeting therapies. Additionally, the compound shows antiviral properties by inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM, with moderate inhibition rates observed. It also inhibits the SARS-CoV-2 3CL-Pro protease by 10.85% at 20 µM concentration. Furthermore, 4-Borono-L-phenylalanine exhibits cytotoxic effects against human U87MG and LN229 glioblastoma cells and mouse 3T3 fibroblasts, demonstrating differential uptake across these cell types with potential antitumor implications. The compound also presents inhibitory activity against the human HDAC6 enzyme, albeit with low inhibition percentages in different enzymatic assays. In biodistribution studies with Wistar rats, the compound accumulates in brain gray matter and tumor tissues, suggesting neuroactive and antitumor properties based on its tissue-specific distribution. Lastly, it reduces viability in human fibroblasts at concentrations between 0.01 and 3 mM, indicating general cytotoxicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	4-Borono-L-phenylalanine has antitumor activity and may be used in clinical trials of boron neutron capture therapy for the treatment of melanoma and glioblastoma multiforme.
别名	L-p-Boronophenylalanine, 4-硼-L-苯基丙氨酸, (s)-2-amino-3-(4-boronophenyl)propanoic acid

化学信息

分子量	209.01
分子式	C₉H₁₂BNO₄
CAS No.	76410-58-7
Smiles	N[C@@H](Cc1ccc(cc1)B(O)O)C(O)=O

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
溶解度信息	DMSO: < 1 mg/mL (insoluble or slightly soluble)

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请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。