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顶部相关产品产品介绍化学信息储存和溶解信息计算器

2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-

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纯度: 96.04%

货号 TN7180Cas号 213473-00-8

别名 Meridianin C, 4-(5-溴-1H-吲哚-3-基)嘧啶-2-胺

2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)- (Meridianin C)是一种海洋来源的天然产物，存在于Aplidium meridianum。

2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
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2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-

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Rating icon 很棒

纯度: 96.04%

货号 TN7180 别名 Meridianin C, 4-(5-溴-1H-吲哚-3-基)嘧啶-2-胺Cas号 213473-00-8

2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)- (Meridianin C)是一种海洋来源的天然产物，存在于Aplidium meridianum。

规格价格库存数量
1 mg
¥ 128
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2 mg
¥ 192
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5 mg
¥ 283
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10 mg
¥ 424
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25 mg
¥ 764
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50 mg
¥ 1,180
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100 mg
¥ 1,835
待询
1 mL x 10 mM (in DMSO)
¥ 270
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纯度: 96.04%
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产品介绍

2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)- AI Summary
2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)- exhibits a diverse range of bioactivities, notably inhibiting multiple kinases such as cyclin-dependent kinases (CDK1, CDK5), protein kinase A (PKA), protein kinase G (PKG), glycogen synthase kinase-3 beta (GSK-3β), and casein kinase I (CK1). Specifically, it demonstrates potent inhibition of human GSK-3β with an IC50 of 2000.0 nM and of PIM1 kinase with an IC50 of 1000.0 nM. The compound also displays significant cytotoxicity against various cell lines, including mouse LMM3 cells (IC50 of 9300.0 nM), human MCF7 cells (IC50 of 24000.0 nM), and mouse HT22 cells (IC50 of 9300.0 nM). Additionally, it inhibits rat recombinant GST-tagged DYRK1A (IC50 of 330.0 nM) and human recombinant GST-tagged CLK1 (IC50 of 220.0 nM). 2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)- shows strong antimalarial activity against Plasmodium falciparum D6 and W2 strains, with IC50 values ranging from 11,000 to 14,000 nM. It also demonstrates antimicrobial activity against Cryptococcus neoformans, antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC90 of 111,100 nM), and antimicrobial activity against Leishmania donovani, showing selectivity over mammalian cells. Its potential therapeutic specificity is notable, given its selective toxicity toward microbial versus mammalian cells. In addition to these activities, 2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)- inhibits various cytochrome P450 enzymes, indicating it could modulate drug metabolism. Its inhibitory effects are moderate to strong on CYP1A1, CYP1A2, and CYP3A4, and weaker against CYP1B1, CYP2D6, CYP2C9, and CYP2C19. Furthermore, it exhibits antibiofilm activity against Mycobacterium smegmatis mc2 155 with an IC50 of 22,700.0 nM for inhibiting biofilm formation, and it can disperse preformed biofilms, though at higher concentrations (EC50 > 50,000.0 nM). Overall, 2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)- presents a multi-targeted therapeutic potential through its myriad bioactivities..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)- (Meridianin C) is a marine derived natural products found in Aplidium meridianum.
别名Meridianin C, 4-(5-溴-1H-吲哚-3-基)嘧啶-2-胺
化学信息
分子量289.13
分子式C12H9BrN4
CAS No.213473-00-8
SmilesNc1nccc(n1)-c1c[nH]c2ccc(Br)cc12
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 11 mg/mL (38.05 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.4587 mL17.2933 mL34.5865 mL172.9326 mL
5 mM0.6917 mL3.4587 mL6.9173 mL34.5865 mL
10 mM0.3459 mL1.7293 mL3.4587 mL17.2933 mL
20 mM0.1729 mL0.8647 mL1.7293 mL8.6466 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
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