2,3-Dibromomaleinimide

Name: 2,3-Dibromomaleinimide
Brand: TargetMol
SKU: TN7161
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.57%

货号 TN7161Cas号 1122-10-7

别名 3,4-二溴-1H-吡咯-2,5-二酮, 3,4-Dibromopyrrole-2,5-dione, 3,4-dibromo-1h-pyrrole-2,5-dione

2,3-Dibromomaleinimide (3,4-Dibromopyrrole-2,5-dione) 是一种海洋来源的天然产物，存在于Axinella brevistyla。

2,3-Dibromomaleinimide

一键复制产品信息

很棒

纯度: 99.57%

货号 TN7161 别名 3,4-二溴-1H-吡咯-2,5-二酮, 3,4-Dibromopyrrole-2,5-dione, 3,4-dibromo-1h-pyrrole-2,5-dioneCas号 1122-10-7

2,3-Dibromomaleinimide (3,4-Dibromopyrrole-2,5-dione) 是一种海洋来源的天然产物，存在于Axinella brevistyla。

规格	价格	库存	数量
100 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 150	现货

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产品介绍

2,3-Dibromomaleinimide AI Summary

2,3-Dibromomaleinimide has demonstrated significant cytotoxicity against various cell lines, specifically mouse L1210 cells with an IC50 value of 0.66 µg/mL and 2580.0 nM, and HEK293 cells with a CC50 value of 3284.0 nM. It exhibits bioactivity related to the inhibition of the AcrAB-TolC efflux pump in Escherichia coli, enhancing the effectiveness of several antibiotics, such as chloramphenicol, tetracycline, piperacillin, levofloxacin, kanamycin, erythromycin, and ciprofloxacin, through modulation of efflux pump mechanisms. Despite its notable antimicrobial potentiation effects in E. coli, the compound does not exhibit direct antibacterial activity against multiple bacterial pathogens including E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Pseudomonas aeruginosa PAO397, and Staphylococcus aureus MRSA at concentrations up to 20,000 nM. Moreover, 2,3-Dibromomaleinimide shows antifungal activity against Candida albicans and Cryptococcus neoformans with MIC values of 20,000 nM and 10,000 nM, respectively. Importantly, it does not cause hemolysis of human red blood cells at concentrations exceeding 20.0 µM, indicating a level of safety in hemolytic potential..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2,3-Dibromomaleinimide (3,4-Dibromopyrrole-2,5-dione) is a marine derived natural products found in Axinella brevistyla.
别名	3,4-二溴-1H-吡咯-2,5-二酮, 3,4-Dibromopyrrole-2,5-dione, 3,4-dibromo-1h-pyrrole-2,5-dione

化学信息

分子量	254.86
分子式	C₄HBr₂NO₂
CAS No.	1122-10-7
Smiles	BrC1=C(Br)C(=O)NC1=O
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (196.19 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9237 mL	19.6186 mL	39.2372 mL	196.1861 mL
5 mM	0.7847 mL	3.9237 mL	7.8474 mL	39.2372 mL
10 mM	0.3924 mL	1.9619 mL	3.9237 mL	19.6186 mL
20 mM	0.1962 mL	0.9809 mL	1.9619 mL	9.8093 mL
50 mM	0.0785 mL	0.3924 mL	0.7847 mL	3.9237 mL
100 mM	0.0392 mL	0.1962 mL	0.3924 mL	1.9619 mL