18:1 PEG3000 PE is a PEG lipid functional terminal group utilized in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Liposome nanoparticles (LNPs), modified with biotin and carboxy terminals, can couple with other biomolecules. Such functionalized nanoparticles are employed for targeted labeling of specific cell proteins. Using streptavidin as a linker, the biotinylated PEG lipid-conjugated polymer nanoparticles can bind with biotinylated antibodies on cell surface receptors, providing utility in fluorescence-based imaging and sensing.