18:0 mPEG750 PE (ammonium) serves as a PEG lipid functional terminal for synthesizing liposomes (LPs) in the design of conjugated polymer nanoparticles. Liposomal nanoparticles (LNPs) featuring biotin modification and carboxyl terminals can couple with other biomolecules. These functionalized nanoparticles are applicable for targeting specific cellular proteins. Utilizing streptavidin as a linker, the biotinylated PEG lipid-conjugated polymer nanoparticles can bind with biotinylated antibodies on cell surface receptors, enabling fluorescence-based imaging and sensing applications.