Name: 12-O-Tiglyl-phorbol 13-dodecanoate
Brand: TargetMol
SKU: TN13615
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a promising inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of oral APOL2 inhibitors. It exhibits no significant toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series can inhibit the expression of fibronectin, type I collagen, and α-smooth muscle actin in hepatic stellate cells. This compound can be isolated from the Euphorbia fischeriana plant and is useful for hepatic fibrosis research.
体外活性	12-O-Tiglyl-phorbol 13-dodecanoate 同系物 TD1 在 10 μM 处理 48 h 条件下，可显著抑制 TGF-β1 刺激的 LX-2 细胞中纤连蛋白的表达。
体内活性	12-O-Tiglyl-phorbol 13-dodecanoate 同系物 TD1（5-20 mg/kg; p.o.; 每 2 天 1 次; 5 w）可剂量依赖性减轻四氯化碳诱导的小鼠肝纤维化，且 20 mg/kg 时其疗效与 200 mg/kg Pirfenidone 相当。

化学信息

分子量	628.84
分子式	C₃₇H₅₆O₈
CAS No.	37394-32-4
Smiles	O(C(CCCCCCCCCCC)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(/C(=C/C)/C)=O)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

12-O-Tiglyl-phorbol 13-dodecanoate