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IDO

IDO

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T8214 Kushenol E
苦参醇E
99119-72-9 98%
Flemiphilippinin D 是一种分离自Sophora flavescens中的类黄酮,是一种IDO1的非竞争性抑制剂,其IC50=7.7 µM,Ki=为 9.5 µM,具有抗肿瘤特性。
T3548 Epacadostat
艾卡哚司他
1204669-58-8 99.92%
Epacadostat 是选择性的IDO1抑制剂,IC50=71.8 nM。
T4307 PF-06840003
化合物PF06840003
198474-05-4 99.89%
PF06840003 是口服具有活力的、选择性的IDO-1抑制剂,抑制 hIDO-1, dIDO-1和 mIDO-1 的IC50分别为 0.41 μM, 0.59 μM,和 1.5 μM。
T6407 β-Lapachone
化合物Beta-Lapachone
4707-32-8 99.86%
Beta-Lapachone 是一种萘醌类天然产物,是拓扑异构酶 I 抑制剂,通过抑制细胞周期进程来诱导细胞凋亡。
T4532 Linrodostat
化合物Linrodostat
1923833-60-6 99.84%
Linrodostat 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂,能够有效抑制IDO1-HEK293 细胞,其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
T20513 IDO1-IN-1
2-肼基苯并噻唑
615-21-4 99.61%
IDO1-IN-1 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
T11616 IDO-IN-13
化合物IDO-IN-13
2291164-02-6 99.57%
IDO-IN-13 是indoleamine 2,3-dioxygenase 1 抑制剂,EC50=17 nM,摘自专利 WO2019040102A1,example 43。
T10199 GNF-PF-3777
化合物GNF-PF-3777
77603-42-0 99.47%
GNF-PF-3777 是人吲哚胺2,3-双加氧酶 2 (hIDO2) 抑制剂,能够降低IDO2活性,Ki=为 0.97 μM。
T2647 IDO5L
化合物INCB024360 analogue
914471-09-3 99%
INCB024360 analogue 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,IC50=67 nM。
T9164 BMS-986242
化合物BMS-986242
1923844-48-7 98.25%
BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂,可用于研究癌症。
T11901 IDO1-IN-5
化合物IDO1-IN-5
2166616-75-5 96.7%
IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂,能够与缺乏血红素的 apo-IDO1 结合,但无法与成熟血红素的 IDO1 结合。
T11615 IDO-IN-12
化合物IDO-IN-12
1888341-29-4 98%
IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
T11627 IACS-8968 R-enantiomer
化合物 T11627
2239305-67-8 98%
IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11614 IDO-IN-11
化合物 T11614
1888378-32-2 98%
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T11628 IACS-8968 S-enantiomer
化合物 T11628
2239305-70-3 98%
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11626 IACS-8968
化合物 T11626
2144425-14-7 98%
IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11621 IDO-IN-8
化合物 T11621
1402837-77-7 98%
IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11619 IDO-IN-5
化合物 T11619
1402837-79-9 98%
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11620 IDO-IN-6
化合物 T11620
1402837-76-6 98%
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11617 IDO-IN-3
化合物 T11617
2070018-30-1 98%
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
Kushenol E
T8214
Flemiphilippinin D 是一种分离自Sophora flavescens中的类黄酮,是一种IDO1的非竞争性抑制剂,其IC50=7.7 µM,Ki=为 9.5 µM,具有抗肿瘤特性。
Epacadostat
T3548
Epacadostat 是选择性的IDO1抑制剂,IC50=71.8 nM。
PF-06840003
T4307
PF06840003 是口服具有活力的、选择性的IDO-1抑制剂,抑制 hIDO-1, dIDO-1和 mIDO-1 的IC50分别为 0.41 μM, 0.59 μM,和 1.5 μM。
β-Lapachone
T6407
Beta-Lapachone 是一种萘醌类天然产物,是拓扑异构酶 I 抑制剂,通过抑制细胞周期进程来诱导细胞凋亡。
Linrodostat
T4532
Linrodostat 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂,能够有效抑制IDO1-HEK293 细胞,其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
IDO1-IN-1
T20513
IDO1-IN-1 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
IDO-IN-13
T11616
IDO-IN-13 是indoleamine 2,3-dioxygenase 1 抑制剂,EC50=17 nM,摘自专利 WO2019040102A1,example 43。
GNF-PF-3777
T10199
GNF-PF-3777 是人吲哚胺2,3-双加氧酶 2 (hIDO2) 抑制剂,能够降低IDO2活性,Ki=为 0.97 μM。
IDO5L
T2647
INCB024360 analogue 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,IC50=67 nM。
BMS-986242
T9164
BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂,可用于研究癌症。
IDO1-IN-5
T11901
IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂,能够与缺乏血红素的 apo-IDO1 结合,但无法与成熟血红素的 IDO1 结合。
IDO-IN-12
T11615
IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
IACS-8968 R-enantiomer
T11627
IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
IDO-IN-11
T11614
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
IACS-8968 S-enantiomer
T11628
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
IACS-8968
T11626
IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
IDO-IN-8
T11621
IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
IDO-IN-5
T11619
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
IDO-IN-6
T11620
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
IDO-IN-3
T11617
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
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