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IDO

IDO

Indoleamine-pyrrole 2,3-dioxygenase (IDO) is a heme-containing enzyme physiologically expressed in several tissues and cells, such as the small intestine, lungs, female genital tract or placenta.IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway. IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.
TargetMol
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Cat. No. Product Name CAS No. Purity Chemical Structure
T11620 IDO-IN-6
化合物 T11620
1402837-76-6 98%
TargetMol Chemical Structure IDO-IN-6
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11626 IACS-8968
化合物 T11626
2144425-14-7 98%
TargetMol Chemical Structure IACS-8968
IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T8214 Kushenol E
苦参醇E
99119-72-9 98%
TargetMol Chemical Structure Kushenol E
Kushenol E (Flemiphilippinin D) 是一种分离自Sophora flavescens 中的类黄酮,是一种IDO1的非竞争性抑制剂,其IC50=7.7 µM,Ki=为 9.5 µM,具有抗肿瘤特性。
T11621 IDO-IN-8
化合物 T11621
1402837-77-7 98%
TargetMol Chemical Structure IDO-IN-8
IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11619 IDO-IN-5
化合物 T11619
1402837-79-9 98%
TargetMol Chemical Structure IDO-IN-5
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11614 IDO-IN-11
化合物 T11614
1888378-32-2 98%
TargetMol Chemical Structure IDO-IN-11
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T11627 IACS-8968 R-enantiomer
化合物 T11627
2239305-67-8 98%
TargetMol Chemical Structure IACS-8968 R-enantiomer
IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11617 IDO-IN-3
化合物 T11617
2070018-30-1 98%
TargetMol Chemical Structure IDO-IN-3
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
T11622 IDO-IN-9
化合物 T11622
1888378-12-8 98%
TargetMol Chemical Structure IDO-IN-9
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T11624 IDO1-IN-2
化合物 T11624
2346614-58-0 98%
TargetMol Chemical Structure IDO1-IN-2
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
T11628 IACS-8968 S-enantiomer
化合物 T11628
2239305-70-3 98%
TargetMol Chemical Structure IACS-8968 S-enantiomer
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T4307 PF-06840003
化合物PF06840003
198474-05-4 99.89%
TargetMol Chemical Structure PF-06840003
PF-06840003 (EOS200271) 是口服具有活力的、选择性的IDO-1抑制剂,抑制 hIDO-1, dIDO-1和 mIDO-1 的IC50分别为 0.41 μM, 0.59 μM,和 1.5 μM。
T6407 β-Lapachone
化合物Beta-Lapachone
4707-32-8 99.86%
TargetMol Chemical Structure β-Lapachone
β-Lapachone (ARQ-501) 是一种萘醌类天然产物,是拓扑异构酶 I 抑制剂,通过抑制细胞周期进程来诱导细胞凋亡。
T4532 Linrodostat
化合物Linrodostat
1923833-60-6 99.84%
TargetMol Chemical Structure Linrodostat
Linrodostat (BMS-986205) 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1(IDO1) 抑制剂,能够有效抑制 IDO1-HEK293 细胞,其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
T20513 IDO1-IN-1
2-肼基苯并噻唑
615-21-4 99.61%
TargetMol Chemical Structure IDO1-IN-1
IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
T11615 IDO-IN-12
化合物IDO-IN-12
1888341-29-4 99.61%
TargetMol Chemical Structure IDO-IN-12
IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
T11616 IDO-IN-13
化合物IDO-IN-13
2291164-02-6 99.57%
TargetMol Chemical Structure IDO-IN-13
IDO-IN-13 (GS-4361) 是 indoleamine 2,3-dioxygenase 1 抑制剂,EC50=17 nM。
T10199 GNF-PF-3777
化合物GNF-PF-3777
77603-42-0 99.47%
TargetMol Chemical Structure GNF-PF-3777
GNF-PF-3777 (8-Nitrotryptanthrin) 是人吲哚胺2,3-双加氧酶 2 (hIDO2) 抑制剂,能够降低IDO2活性,Ki=为 0.97 μM。
T3548 Epacadostat
艾卡哚司他
1204669-58-8 98.56%
TargetMol Chemical Structure Epacadostat
Epacadostat (INCB 024360) 是选择性的IDO1抑制剂,IC50=71.8 nM。
T9164 BMS-986242
化合物BMS-986242
1923844-48-7 98.25%
TargetMol Chemical Structure BMS-986242
BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂,可用于研究癌症。
IDO-IN-6
T11620
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
IACS-8968
T11626
IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
Kushenol E
T8214
Kushenol E (Flemiphilippinin D) 是一种分离自Sophora flavescens 中的类黄酮,是一种IDO1的非竞争性抑制剂,其IC50=7.7 µM,Ki=为 9.5 µM,具有抗肿瘤特性。
IDO-IN-8
T11621
IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
IDO-IN-5
T11619
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
IDO-IN-11
T11614
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
IACS-8968 R-enantiomer
T11627
IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
IDO-IN-3
T11617
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
IDO-IN-9
T11622
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
IDO1-IN-2
T11624
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
IACS-8968 S-enantiomer
T11628
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
PF-06840003
T4307
PF-06840003 (EOS200271) 是口服具有活力的、选择性的IDO-1抑制剂,抑制 hIDO-1, dIDO-1和 mIDO-1 的IC50分别为 0.41 μM, 0.59 μM,和 1.5 μM。
β-Lapachone
T6407
β-Lapachone (ARQ-501) 是一种萘醌类天然产物,是拓扑异构酶 I 抑制剂,通过抑制细胞周期进程来诱导细胞凋亡。
Linrodostat
T4532
Linrodostat (BMS-986205) 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1(IDO1) 抑制剂,能够有效抑制 IDO1-HEK293 细胞,其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
IDO1-IN-1
T20513
IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
IDO-IN-12
T11615
IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
IDO-IN-13
T11616
IDO-IN-13 (GS-4361) 是 indoleamine 2,3-dioxygenase 1 抑制剂,EC50=17 nM。
GNF-PF-3777
T10199
GNF-PF-3777 (8-Nitrotryptanthrin) 是人吲哚胺2,3-双加氧酶 2 (hIDO2) 抑制剂,能够降低IDO2活性,Ki=为 0.97 μM。
Epacadostat
T3548
Epacadostat (INCB 024360) 是选择性的IDO1抑制剂,IC50=71.8 nM。
BMS-986242
T9164
BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂,可用于研究癌症。
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