IDO

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.

Cat. No.	Product Name	CAS No.	Purity
T8214	Kushenol E 苦参醇E	99119-72-9	98%
T8214	Flemiphilippinin D 是一种分离自Sophora flavescens中的类黄酮，是一种IDO1的非竞争性抑制剂，其IC50=7.7 µM，Ki=为 9.5 µM，具有抗肿瘤特性。
T3548	Epacadostat 艾卡哚司他	1204669-58-8	99.92%
T3548	Epacadostat 是选择性的IDO1抑制剂，IC50=71.8 nM。
T4307	PF-06840003 化合物PF06840003	198474-05-4	99.89%
T4307	PF06840003 是口服具有活力的、选择性的IDO-1抑制剂，抑制 hIDO-1， dIDO-1和 mIDO-1 的IC50分别为 0.41 μM， 0.59 μM，和 1.5 μM。
T6407	β-Lapachone 化合物Beta-Lapachone	4707-32-8	99.86%
T6407	Beta-Lapachone 是一种萘醌类天然产物，是拓扑异构酶 I 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。
T4532	Linrodostat 化合物Linrodostat	1923833-60-6	99.84%
T4532	Linrodostat 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂，能够有效抑制IDO1-HEK293 细胞，其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
T20513	IDO1-IN-1 2-肼基苯并噻唑	615-21-4	99.61%
T20513	IDO1-IN-1 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
T11616	IDO-IN-13 化合物IDO-IN-13	2291164-02-6	99.57%
T11616	IDO-IN-13 是indoleamine 2,3-dioxygenase 1 抑制剂，EC50=17 nM，摘自专利 WO2019040102A1，example 43。
T10199	GNF-PF-3777 化合物GNF-PF-3777	77603-42-0	99.47%
T10199	GNF-PF-3777 是人吲哚胺2，3-双加氧酶 2 (hIDO2) 抑制剂，能够降低IDO2活性，Ki=为 0.97 μM。
T2647	IDO5L 化合物INCB024360 analogue	914471-09-3	99%
T2647	INCB024360 analogue 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，IC50=67 nM。
T9164	BMS-986242 化合物BMS-986242	1923844-48-7	98.25%
T9164	BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂，可用于研究癌症。
T11901	IDO1-IN-5 化合物IDO1-IN-5	2166616-75-5	96.7%
T11901	IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂，能够与缺乏血红素的 apo-IDO1 结合，但无法与成熟血红素的 IDO1 结合。
T11615	IDO-IN-12 化合物IDO-IN-12	1888341-29-4	98%
T11615	IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
T11627	IACS-8968 R-enantiomer 化合物 T11627	2239305-67-8	98%
T11627	IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11614	IDO-IN-11 化合物 T11614	1888378-32-2	98%
T11614	IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T11628	IACS-8968 S-enantiomer 化合物 T11628	2239305-70-3	98%
T11628	IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11626	IACS-8968 化合物 T11626	2144425-14-7	98%
T11626	IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11621	IDO-IN-8 化合物 T11621	1402837-77-7	98%
T11621	IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11619	IDO-IN-5 化合物 T11619	1402837-79-9	98%
T11619	IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11620	IDO-IN-6 化合物 T11620	1402837-76-6	98%
T11620	IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11617	IDO-IN-3 化合物 T11617	2070018-30-1	98%
T11617	IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).