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Search Results for " vasoconstriction "

42

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0993	Methoxamine hydrochloride Methoxamine HCl,盐酸甲氧明	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Methoxamine hydrochloride (Methoxamine HCl) 是一种 alpha1 肾上腺素能受体的选择性激动剂。它通过 Prazosin 敏感机制在兔肺动脉显著增加 ATP、ADP 和 AMP 的溢出，但不增加腺苷的溢出。它引起血管收缩和外周血管阻力增加。
T5850	Benzamil Benzamil (hydrochloride)	Na+/Ca2+ Exchanger; Sodium Channel	Membrane transporter/Ion channel
	Benzamil 是 Amiloride 类似物，是 Na+/Ca2+交换体抑制剂，抑制 TRPP3 介导的 Ca2+激活电流，IC50为 1.1 μM。它也是一种非选择性上皮钠通道 (ENaC) 阻滞剂，能增强肌源性血管收缩。
T13920L	Terlipressin Acetate Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素	Vasopressin Receptor	GPCR/G Protein
	Terlipressin Acetate 是一种高度选择性的加压素 V1 受体激动剂，对氧和葡萄糖剥夺/再氧合 (OGD/R) 诱导的肠上皮细胞损伤 (IEC-6) 具有抗炎和抗氧化作用，可用于肝肾综合征和耐去甲肾上腺素的败血性休克的研究。
T0446	Naphazoline hydrochloride 盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naphazoline hydrochloride (Naphazoline HCl) 是一种咪唑啉衍生物，是一种眼血管收缩剂。
T21445	Naphazoline AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naphazoline (Naphcon-a) 是一种具有显着 α 肾上腺素能活性的拟交感神经化合物。萘甲唑啉可用作血管收缩剂，当应用于粘膜时可快速减少肿胀。
T1066L	Ketanserin tartrate KJK 945 tartrate,KJK-945 tartrate,KJK945 tartrate	5-HT Receptor; Serotonin Transporter; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ketanserin tartrate (KJK-945 tartrate) 是 5-HT2A 受体和α1-肾上腺素能受体拮抗剂，具有抗高血压活性，抑制血清素诱导的血管收缩和血小板活化，可用于研究系统性硬化症。
TP2446L	Angiotensin amide acetate 血管紧张素胺,Angiotensin amide acetate(53-73-6 Free base)	Others	Others
	Angiotensin amide acetate 是Angiotensin amide 的衍生物。Angiotensin amide 是一种八肽酰胺，可以通过血管收缩来提高血压。
T2400	Candesartan Cilexetil TCV-116,坎地沙坦酯,坎地沙坦西酯	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Candesartan Cilexetil (TCV-116) 是一种血管紧张素II 拮抗剂，可用于治疗高血压。
T21231	Almotriptan 阿莫曲坦,LAS 31416,阿莫曲普坦	5-HT Receptor	GPCR/G Protein; Neuroscience
	Almotriptan (LAS 31416) 是一种用于研究偏头痛的5-HT1B/1D 受体激动剂。
TP1295	Angiotensin I (human, mouse, rat) Angiotensin 1 Human,血管紧张素 1 (人)	Others	Others
	Angiotensin I (human, mouse, rat) 是血管紧张素Ⅱ的前体物质，在血管紧张素转化酶 (ACE) 的参与下裂解成血管紧张素Ⅱ。
T21447	Tolazoline Priscol,妥拉苏林,Priscoline,Pridazole,Divascol,Vasimid,Benzalolin	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tolazoline (Benzalolin) 是一种竞争性的α-肾上腺素受体拮抗剂。
T1158	Phenoxybenzamine hydrochloride 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl	CaMK; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。
T1066	Ketanserin R41468,凯他色林,Ketanserin tartrate,酮色林,Ketanserinum	Potassium Channel; 5-HT Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Ketanserin (Ketanserinum) 是一种喹唑啉衍生物和 5-羟色胺受体亚型 2 拮抗剂，具有潜在的抗高血压和抗血小板活性。它也浓度依赖性抑制 hERG 电流，IC50为 0.11 μM。
T1484L	Perindopril erbumine 培哚普利叔丁胺,培哚普利叔丁胺盐,S9490-3,Perindopril tert-butylamine salt	Apoptosis; RAAS; MRP	Apoptosis; Endocrinology/Hormones; Immunology/Inflammation
	Perindopril erbumine (S9490-3) 是一种长效血管紧张素转换酶抑制剂。
TP2158	TRV-120027 TFA TRV-120027 TFA (1234510-46-3 free base)	RAAS; Arrestin	Endocrinology/Hormones; GPCR/G Protein
	TRV-120027 TFA 是一种血管紧张素 II 介导的血管收缩抑制剂，可增加心肌细胞的收缩力。它是一种偏向 β-arrestin-1 的 AT1R 激动剂，可与 ß-arrestins 结合，同时阻断 G 蛋白信号传导。它通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌，并促进在质膜上形成由 AT1R-β-arrestin-1-TRPC3-PLCγ 组成的大分子复合物。
T6602	Naratriptan hydrochloride Naratriptan HCl,Amerge,Naramig,盐酸那拉曲坦,GR-85548A hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Naratriptan hydrochloride (GR-85548A hydrochloride) 是一种5-HT1受体激动剂，有抗偏头疼特性。它还可以通过刺激三叉神经系统感觉神经末梢上的 5-HT1D/1B 受体来发挥其作用，从而减少促炎神经肽的释放。
T19665	Amastatin hydrochloride 氨肽酶抑制剂盐酸盐,BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280
	Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction.
T25922	PD 142893 PD-142893,PD142893
	PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.
T34862	Thromboxane A2 Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2
	Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction.
TP2158L	TRV-120027	Others	Others
	TRV120027 is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility.
TP2446	Angiotensin amide Angiotensinamide,Hypertensine,Angiotensin,NSC 107678,NSC-107678
	Angiotensin amide, an octapeptide amide, can be used to increase blood pressure by vasoconstriction.
TP1706	BQ-3020 TFA (143113-45-5 free base) BQ-3020 TFA
	BQ-3020 (TFA) is a selective ETB receptor agonist that inhibits [125I] et-1 binding to the ETB receptor in the cerebellum with a 0.2nm IC50, causing vasoconstriction.
T70837	Rimegepant sulfate hydrate
	Rimegepant, also known as BMS-927711 and BHV-3000, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraines. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS-927711 is superior to placebo at several different doses (75 mg, 150 mg, and 300 mg) and has an excellent tolerability profile.
T36153	15(S)-15-methyl Prostaglandin D2 15(S)-15-methyl Prostaglandin D2
	15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters (200-fold more potent than PGD2).
T75771	BQ-3020 TFA
	BQ-3020 (TFA) 是一种选择性的内皮素受体 B (ETBreceptor) 激动剂，抑制小脑 [125I]ET-1 与 ETB 受体结合，IC50值为 0.2 nM。BQ-3020 (TFA) 可导致血管收缩。
T60425	Tetrahydrozoline nitrate
	Tetrahydrozoline (Tetryzoline) nitrate 是咪唑啉的衍生物。它是一种引起血管收缩的α-肾上腺素能 (α-adrenergic) 激动剂。Tetrahydrozoline 广泛用于鼻充血和结膜充血的研究。
T22573	Angiotensin 1/2 (2-7)	Others	Others
	Angiotensin I/II (2-7) is a peptide that contains the amino acids 2-7 and is converted from Angiotensin I/II peptide. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin also stimulates th
T36209	15-keto Prostaglandin A1 15-keto Prostaglandin A1
	Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase. It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations. 15-keto PGA1, given at a concentration of 6 μM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II.
T31845	Forasartan SC52458,SC 52458,SC-52458
	Forasartan is a non - peptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan and angiotensin II compete to bind AT1 receptor subtypes in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction, lead
T75772	[Ala1,3,11,15]-Endothelin (53-63) (TFA)
	[Ala1,3,11,15]-Endothelin (53-63) (TFA) 是一种ETB 激动剂。[Ala1,3,11,15]-Endothelin (53-63) (TFA) 对 ETB 具有选择性，IC50值范围为 0.33 nM 至 0.61 nM。[Ala1,3,11,15]-Endothelin (53-63) (TFA) 可用于血管收缩的研究。
T82933	Auriculin A
	Auriculin A是一种合成ANF，它对血液动力学具有显著效应。该化合物可阻断犬的肾血管收缩，并在兔子的后肢灌注压、心率及动脉血压的全身调节中发挥作用。
T35598	Neuromedin U-25 (human) (trifluoroacetate salt)
	Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery ...
T71211	Rizatriptan-d6 benzoate salt
	Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-HT1B and 5-HT1D receptors over 5-HT1A receptors. Rizatriptan induces vasoconstriction in isolated human middle meningeal arteries. In vivo, rizatriptan reduces head grooming, the number of oculotemporal strokes, eye blinking, and one-eye closures in a Cacna1a mutant transgenic mou...
T36216	19(R)-HETE
	19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% of the (S) and (R) stereoisomers, respectively. Both 19(S)- and 19(R)-HETE are potent vasodilators of renal preglomerular vessels. However, 19(R)-HETE at 1 μM completely blocks 20-HETE-induced vasoconstriction of renal arterioles, whereas 19(S)-HETE remains inactive.
T33631	Neocuproine Neocuproin
	Neocuproine 是一种铜（I）螯合剂，可增强电场刺激引起的输精管收缩的嘌呤能成分，常被用作配位试剂和铜离子检测剂。Neocuproine 与铜离子形成稳定的络合物，并可在某些化学反应和分析方法中起到催化作用。Neocuproine 作为铁和钴上的氧化还原活性配体平台，对NSC34细胞氧化损伤的保护作用。
T35467	(±)18-HETE
	(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, whereas 18(S)-HETE does not affect perfusion pressure. 18-HETE has negligible effects on ATPase activity. 18(R)-HETE at 1 μM completely blocks 20-HETE-induced vasoconstriction of renal arterioles.
T78096	BQ-3020 ammonium	Endothelin Receptor	GPCR/G Protein
	BQ-3020 ammonium 是一种内皮素受体（endothelin receptor）(ETB receptor) 激动剂。它在阻断[125I]ET-1与猪小脑ETB受体的结合实验中显示出IC50值为0.2 nM。此外，BQ-3020 ammonium能够引致兔肺动脉血管收缩以及猪膀胱颈的松弛，因此可作为心血管疾病研究的工具。
TP2194	Neuropeptide Y (scrambled)	Others	Others
	Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that exerts its activity via G-protein-coupled receptors. NPY is widely distributed in the peripheral and central nervous systems. It modulates a variety of physiological processes, e.g. the central reg
T37969	12(S)-HpETE
	12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and e...
T83840	Uridine-5'-O-(3-thiotriphosphate) sodium UTP-γ-S
	Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) 是UTP的一种抗水解衍生物，是嘌呤P2Y2受体的激动剂。在表达人类P2Y2受体的1321N1星形胶质瘤细胞中，其可诱导肌醇磷酸盐的形成（EC50 = 240 nM），并且在来自囊性纤维化患者的原代鼻上皮细胞中以浓度依赖的方式诱导氯离子分泌。UTP-γ-S在分离的人类冠状动脉中诱导血管收缩（EC50 = 25.1 µM）。
T36070	(±)5(6)-EET
	5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhib...
T83677	Neuropeptide Y (porcine, bovine) TFA NPY (porcine, bovine)
	神经肽Y（Neuropeptide Y, NPY）是一种参与调节食欲、血管收缩、心脏收缩力和肠道分泌的神经肽，同时也是NPY受体Y1、Y2和Y5的激动剂。它在全身范围内表达。NPY能够在表达大鼠Y1或Y2以及表达大鼠Y5的HEK293细胞中选择性抑制由forskolin诱导的cAMP积累，而对表达大鼠Y4受体的L-M(TK-)细胞的影响较小（EC50分别为0.15、2.7、0.66和>1,000 nM)。在分离的豚鼠心脏模型中，NPY能够增加灌注压（EC30 = 1.3 nM）。神经内注射NPY（300 pmol/动物）能够在大鼠中增加食物摄取量。

化合物

Methoxamine hydrochloride

Cat.No: T0993

Synonym: Methoxamine HCl,盐酸甲氧明

Target: Adrenergic Receptor

Cat.No: T5850

Synonym: Benzamil (hydrochloride)

Target: Na+/Ca2+ Exchanger, Sodium Channel

Terlipressin Acetate

Cat.No: T13920L

Synonym: Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素

Target: Vasopressin Receptor

Naphazoline hydrochloride

Cat.No: T0446

Synonym: 盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl

Target: Adrenergic Receptor

Cat.No: T21445

Synonym: AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林

Target: Adrenergic Receptor

Ketanserin tartrate

Cat.No: T1066L

Synonym: KJK 945 tartrate,KJK-945 tartrate,KJK945 tartrate

Target: 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor

Angiotensin amide acetate

Cat.No: TP2446L

Synonym: 血管紧张素胺,Angiotensin amide acetate(53-73-6 Free base)

Target: Others

Candesartan Cilexetil

Cat.No: T2400

Synonym: TCV-116,坎地沙坦酯,坎地沙坦西酯

Target: Apoptosis, RAAS

Cat.No: T21231

Synonym: 阿莫曲坦,LAS 31416,阿莫曲普坦

Target: 5-HT Receptor

Angiotensin I (human, mouse, rat)

Cat.No: TP1295

Synonym: Angiotensin 1 Human,血管紧张素 1 (人)

Target: Others

Cat.No: T21447

Synonym: Priscol,妥拉苏林,Priscoline,Pridazole,Divascol,Vasimid,Benzalolin

Target: Adrenergic Receptor

Phenoxybenzamine hydrochloride

Cat.No: T1158

Synonym: 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Cat.No: T1066

Synonym: R41468,凯他色林,Ketanserin tartrate,酮色林,Ketanserinum

Target: Potassium Channel, 5-HT Receptor, Autophagy

Perindopril erbumine

Cat.No: T1484L

Synonym: 培哚普利叔丁胺,培哚普利叔丁胺盐,S9490-3,Perindopril tert-butylamine salt

Target: Apoptosis, RAAS, MRP

Cat.No: TP2158

Synonym: TRV-120027 TFA (1234510-46-3 free base)

Target: RAAS, Arrestin

Naratriptan hydrochloride

Cat.No: T6602

Synonym: Naratriptan HCl,Amerge,Naramig,盐酸那拉曲坦,GR-85548A hydrochloride

Target: 5-HT Receptor

Amastatin hydrochloride

Cat.No: T19665

Synonym: 氨肽酶抑制剂盐酸盐,BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280

Cat.No: T25922

Synonym: PD-142893,PD142893

Cat.No: T34862

Synonym: Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2

Cat.No: TP2158L

Target: Others

Angiotensin amide

Cat.No: TP2446

Synonym: Angiotensinamide,Hypertensine,Angiotensin,NSC 107678,NSC-107678

BQ-3020 TFA (143113-45-5 free base)

Cat.No: TP1706

Synonym: BQ-3020 TFA

Rimegepant sulfate hydrate

Cat.No: T70837

15(S)-15-methyl Prostaglandin D2

Cat.No: T36153

Synonym: 15(S)-15-methyl Prostaglandin D2

Cat.No: T75771

Tetrahydrozoline nitrate

Cat.No: T60425

Angiotensin 1/2 (2-7)

Cat.No: T22573

Target: Others

15-keto Prostaglandin A1

Cat.No: T36209

Synonym: 15-keto Prostaglandin A1

Cat.No: T31845

Synonym: SC52458,SC 52458,SC-52458

[Ala1,3,11,15]-Endothelin (53-63) (TFA)

Cat.No: T75772

Cat.No: T82933

Neuromedin U-25 (human) (trifluoroacetate salt)

Cat.No: T35598

Rizatriptan-d6 benzoate salt

Cat.No: T71211

Cat.No: T36216

Cat.No: T33631

Synonym: Neocuproin

Cat.No: T35467

BQ-3020 ammonium

Cat.No: T78096

Target: Endothelin Receptor

Neuropeptide Y (scrambled)

Cat.No: TP2194

Target: Others

Cat.No: T37969

Uridine-5'-O-(3-thiotriphosphate) sodium

Cat.No: T83840

Synonym: UTP-γ-S

Cat.No: T36070

Neuropeptide Y (porcine, bovine) TFA

Cat.No: T83677

Synonym: NPY (porcine, bovine)

Cat. No.	Product Name	Target	Signaling Pathways
T2944	Danshensu sodium salt Sodium Danshensu,(±)-DanShenSu sodium salt,丹参素钠,(±)-DanShenSu sodium sal	P450; Autophagy	Autophagy; Metabolism
	Danshensu sodium salt (Sodium Danshensu) 是从中国草本丹参中提取的一种天然产物，可以抑制去氧肾上腺素和CaCl2 在无Ca2+ 培养基中引起的血管收缩。
T4706	Uridine-5'-diphosphate disodium salt UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd,尿苷-5'-二磷酸二钠盐	DNA/RNA Synthesis; Endogenous Metabolite; P2Y Receptor	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Uridine-5'-diphosphate disodium salt (UDP disodium salt) 是一种选择性 P2Y6受体激动剂，EC50为300 nM，对人 P2Y6受体的 pEC50为6.52。它可刺激炎症介质的产生、吞噬作用和血管收缩，催化多种底物的葡糖醛酸糖化反应，用于核酸生物合成。

天然产物

Danshensu sodium salt

Cat.No: T2944

Synonym: Sodium Danshensu,(±)-DanShenSu sodium salt,丹参素钠,(±)-DanShenSu sodium sal

Target: P450, Autophagy

Uridine-5'-diphosphate disodium salt

Cat.No: T4706

Synonym: UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd,尿苷-5'-二磷酸二钠盐

Target: DNA/RNA Synthesis, Endogenous Metabolite, P2Y Receptor

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