type-1 angiotensin ii receptor

E-4177 是一种血管紧张素II-1型受体(AT1R)拮抗剂，可用于研究心血管疾病。

Azilsartan Medoxomil Potassium (TAK-491 Potassium) 是一种具有口服活性的1型血管紧张素 II 受体拮抗剂(IC50: 0.62 nM)。

Olmesartan Medoxomil (Benicar) 是血管紧张素 (angiotensin AT1) 受体选择性抑制剂(IC50:66.2 μM)。

Telmisartan (BIBR 277) 是一种血管紧张素II 1型受体拮抗剂，能够抑制其活性，IC50值为 9.2 nM。

Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂，IC50为1.3 nM。

Azilsartan Medoxomil (TAK-491) 是一种具有口服活性的1型血管紧张素II 受体拮抗剂(IC50:0.62 nM)。

Valsartan (CGP 48933) 是一种血管紧张素 II 受体拮抗剂，有用于高血压和心力衰竭的研究潜力。

Azilsartan (TAK-536) D5 is the deuterium-labeled Azilsartan. Azilsartan is a specific antagonist of the angiotensin II type 1 receptor.

TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

TD-0212 TFA is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

ZD 7155 hydrochloride 是血管紧张素II 受体1型 (AT1 receptor) 拮抗剂。

AT1R antagonist 3 (Compound 1) 是血管紧张素 II 1 型受体 (AT1R) 的拮抗剂，同时也是 L 型钙离子通道 CaV1.2 的抑制剂 (IC50=0.57 μM)。在离体大鼠主动脉实验中，该化合物表现出血管舒张作用 (10 μM, 88.7%)，且在大鼠模型中显示出降压效果。

1H-1-ethyl Candesartan Cilexetil 是 Candesartan cilexetil 批量合成中的一种工艺相关杂质，坎地沙坦酯是一种强效、长效和选择性血管紧张素 II 1 型受体 (AT1) 拮抗剂。

Angiotensin Fragment 1-7 is a type 1 angiotensin II receptor agonist. In the renin-angiotensin system, angiotensin I is cleaved by the angiotensin-converting enzyme to form angiotensin II, which has effects on fluid and electrolyte, as well as homeostasis

L 158809 is an antagonist of the angiotensin II type 1 receptor.

FK-739 is an angiotensin type 1 receptor antagonist. FK 739 inhibits the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane (IC50 = 8.6 nM) without displacing the specific binding of [125I]-angiotensin II to bovine cerebel

UR-7247 是一种新型可口服活性的血管紧张素 II 亚型 I（AT1）受体拮抗剂，具有显著持久的药效。体内研究显示，给药后 4 小时，10 mg UR-7247 与 100 mg losartan 在药效上无显著差异，而体外研究则显示 100 mg losartan 的阻断能力超过 UR-7247，提示 UR-7247 具有较长血浆半衰期，可能与其高亲和力蛋白结合有关，表明其在健康受试者中呈现出长效且耐受性良好的 AT1 阻断作用。

ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. It displaces [125I]-angiotensin II binding in guinea pig adrenal gland membranes with an IC50 value of 3.8 nM.

Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM. In humans, losartan effectively controls hypertension while protecting renal function. Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium. NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.

4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.

Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.

TRV055 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling. TRV055 can be used to develop the Gq-biased AT1R agonists.

TRV055 acetate 是血管紧张素 II 1 型受体的配体，可刺激细胞 Gq 介导的信号传导。

TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonists.