triphosphate

Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM)，HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。

Cytidine 5'-diphosphate trisodium salt (CDP) 可通过尿苷单磷酸激酶 (UMPK) 催化将磷酸基从 ATP 转移到胞苷一磷酸 (CMP) 生成用于合成 DNA 和 RNA 的胞苷三磷酸。

Remdesivir triphosphate 是一种有效的病毒 RNA 依赖的 RNA 聚合酶抑制剂，对RSVRdRp 和 HCVRdRp 的IC50分别为 1.1 µM 和 5 µM。它是 Remdesivir 的活性三磷酸代谢物。

IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) 是一种非竞争特异性人类线粒体 RNA 聚合酶(POLRMT) 抑制剂，可引起 POLRMT 的构象变化，以剂量依赖性方式阻断底物结合和转录。它可降低脱氧核苷三磷酸水平和柠檬酸循环中间体，导致细胞氨基酸水平显著消耗，有用于线粒体转录等相关疾病的研究潜力。

Guanosine-5'-triphosphate disodium salt (5'-GTP disodium salt) 是肌原性细胞分化的增强剂，也是翻译和其他重要细胞过程的能量来源。

5'-GTP trisodium salt hydrate, an activator of the signal-transducing G proteins, serves as a precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola. Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir.

N4-Acetylcytidine triphosphate sodium is an efficient substrate for T7 Polymerase-catalyzed in vitro transcription.

N4-Acetylcytidine triphosphate is an efficient substrate for T7 Polymerase-catalyzed in vitro transcription.

NHC-triphosphate is a weak alternative substrate for the viral polymerase and changes the mobility of the product in polyacrylamide electrophoresis gels.

GTP tritris 在细胞生理和化学过程中扮演多种关键角色，尤其在肌细胞分化及miRNA-肌肉调节因子的调控中起到增强作用。此外，它促进富含鸟苷及其衍生物的外泌体释放，并作为 RNA 合成的活化前体。在线粒体功能方面，GTP 通过协助蛋白质进入基质来启动肽合成，不仅助力甲酰甲硫氨酰-tRNA 与核糖体的结合，还推动多肽链的延长。它也作为磷酸盐及焦磷酸盐的载体，激活G蛋白信号转导路径，调节细胞的增殖与分化。GTP 的水解过程，特别是小 GTPases（如Ras与 Rho）的作用对于细胞的增殖和凋亡是必需的。同样，小 GTPase Rab 也是囊泡对接、融合与形成不可或缺的因素。GTP 不仅限于信号转导，还是 DNA 和 RNA 酶生物合成中的一个能量丰富的前体。

Uridine triphosphate (UTP) 是一种潜在用于治疗肺癌的嘌呤核苷酸P2U受体激动剂。它通过激活P2Y2受体增加人类癌变胰管上皮细胞的增殖。此外，Uridine triphosphate (UTP) 通过激活P2Y2受体，在心脏成纤维细胞中诱导纤维化反应。同时，UTP通过P2Y2嘌呤受体延长豚鼠乳头肌的动作电位时长。

Kinetin triphosphate tetrasodium(KTP tetrasodium)是Kinetin triphosphate的四钠盐形式。Kinetin triphosphate是一种ATP类似物，能够增强帕金森病相关突变体线粒体激酶PINK1(G309D) 和 PINK1(WT)的活性，对神经退行性疾病具有治疗潜力。

Clofarabine-5'-triphosphate 是Clofarabine 经由脱氧胞苷激酶 (dCK) 磷酸化形成的代谢产物。其通过抑制 DNA 合成及 DNA 修复机制，在癌细胞中展现出细胞毒性效果。

Purine riboside-5'-O-triphosphate sodium 是 Nebularine 的活性代谢产物，作为 DNA 引物酶 ATP 和 GTP 聚合活性的抑制剂，其IC50值分别为 35 µM 和 28 µM。此外，Purine riboside-5'-O-triphosphate sodium 还能抑制钙调素依赖性蛋白激酶II (calmodulin-dependent protein kinase II (CaMKII))，其Ki值为 590 µM。

2'-Deoxytubercidin 5'-triphosphate (C7dATP) sodium 是一种脱氧腺苷三磷酸 (dATP) 类似物，能够降低由 G 或 A 残基压缩引发的电泳迁移率异常，这有助于提高 DNA 测序数据的质量。

Formycin triphosphate 是一种 ATP 的荧光类似物，可与酶的活性位点结合并显示出增强的荧光。它是 ATP 的竞争性鸡肝丙酮酸羧化酶 (pyruvate carboxylase) 抑制剂。同时，它能增强心房利钠因子 (ANF) 刺激的鸟苷酸环化酶 (guanylate cyclase) 活性，EC50 大约为 90 μM，并且抑制 ATP 刺激的鸟苷酸环化酶活性，IC50 大约为 100 μM。

(+)-Carbovir triphosphate is an active metabolite of Abacavir. It was used to study the molecular mechanism of inhibition and drug resistance for HIV-1 reverse transcriptase.

4'-Azidothymidine 5'-triphosphate exerts selectively action on both reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases alpha and beta.

Aminoquinol triphosphate may be useful in the treatment of acute necrotising cutaneous leishmaniasis.

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1]. 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-triphosphate will be useful in studies at the molecular level on the relationship of template and substrate in RNA synthesis with chromatin, isolated nuclei or permeable cells, because it does not have any effect on poly (rA) synthesis[1]. [1]. M Saneyoshi, et al. Inhibitory Effects of 3'deoxycytidine 5'-triphosphate and 3'-deoxyuridine 5'-triphosphate on DNA-dependent RNA Polymerases I and II Purified From Dictyostelium Discoideum Cells. Nucleic Acids Res. 1981 Jul 10;9(13):3129-38.

3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1]. 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-triphosphate will be useful in studies at the molecular level on the relationship of template and substrate in RNA synthesis with chromatin, isolated nuclei or permeable cells, because it does not have any effect on poly (rA) synthesis[1].

D-myo-Inositol-1,4,5-triphosphate tripotassium (Ins(1,4,5)-P3 tripotassium) 是一种可引发 Ca2+ 动员的细胞内信号转导系统中的第二信使。

D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,4,6)-P3 (tested as the meso compound) is 9-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.