scavenging activity

Epirosmanol 是含有内酯部分的二萜类化合物。 Epirosmanol 是一种极弱碱性（基本中性）的化合物（基于其 pKa）。

Pyrocatechol（常称catechol或benzene-1,2-diol）是一种苯二醇。该化合物被大规模工业化生产，主要用作农药、香料及香精的前体。其磺酸盐常存在于多种哺乳动物的尿液中。

Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素，具有抗炎活性。 在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中，Aucuparin 抑制肺纤维化。 在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用，其IC50为17.0μM。

Protocatechuic acid (3, 4-Dihydroxybenzoic acid) 是天然的多酚类物质，具有神经保护活性。

Azelaic acid (Anchoic acid) 是头发和皮肤调理剂的组分，可由油酸臭氧分解产生。Azelaic acid 通过抑制微生物细胞原蛋白合成对痤疮丙酸杆菌和表皮葡萄球菌具有抑菌活性。Azelaic acid 还具有抑制色素沉着的功能，这是由于其清除自由基作用。

D-Isofloridoside是一种多糖前体，对酒精诱导的HepG2细胞肝毒性和氧化应激具有保护作用，GSH、SOD和bcl-表达水平升高，GGT、bax、cleaved caspase-3和p38表达水平降低。

Diplacone (DP) 是一种天然存在于 泡桐（Paulownia tomentosa）果实中的 烯丙基化黄酮类化合物。Diplacone 具有抗炎和自由基清除（抗自由基）活性。在涉及 A549 人肺癌细胞 的研究中，Diplacone 被证明可抑制癌细胞的生长和存活，从而展现其潜在的抗癌活性。

5,6,7-Trihydroxy-4'-methoxyflavone是一种抗氧化的天然产物，在DPPH自由基清除活性实验中对PC12细胞的IC50=25.29 μM。

γ-Glutamyl-S-1-propenyl cysteine 是从大蒜中得到的化合物，具有很强的自由基清除活性。

Loganin (Loganoside) 是山茱萸中的主要环烯醚萜苷类天然产物，具有抗炎、抗休克的作用。

Antiarol (3,4,5-trimethoxyphenol) 是一种提取自 Salmaliamalabaricum 中的天然化合物。

Nepitrin (Nepetin-7-glucoside) 分离自Scrophularia striata 中，具有强大的抗炎、抗关节炎作用。

Bergaptol (4-Hydroxybergapten) 是CYP3A4酶脱苄基作用的抑制剂(IC50:24.92 uM)，具有抗癌、抗增殖作用。

3-Isomangostin 可从莽吉柿壳中提取的一种天然产物，是一种乙酰胆碱酯酶选择性抑制剂，也是一种有效的人醛糖还原酶抑制剂，IC50 为 3.48 uM。它抑制 MutT 同源物 1 (MTH1)，IC50 为 52 nM。它具有清除自由基、抗疟原虫和抗癌的活性。

Cimifugin (Cimitin) 是中草药Saposhnikovia divaricate 的一种生物活性成分。它能够调节紧密连接减少上皮衍生的主动关键因子，对过敏性炎症产生抑制作用。

Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。

3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both).3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively).4References1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003). 3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both).3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively).4 References1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003).

Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) reduces tumor growth in an SW1990 mouse xenograft model. |1. Zhang, P., Li, X.-M., Wang, J.-N., et al. New butenolide derivatives from the marine-derived fungus Paecilomyces variotii with DPPH radical scavenging activity. Phytochem. Lett. 11, 85-88 (2015).|2. Sun, W., Luan, S., Qi, C., et al. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Commun. Signal. 17(1), 111 (2019).

Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2]. Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM. [1]. Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749. [2]. Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340.

5-Hydroxyoxindole 是尿酸的一种结构类似物，具有脂质过氧化抑制活性和自由基 DPPH 清除活性，可用于氧化应激介导的疾病的研究。

3'-Hydroxypuerarin 是一种异黄酮，从Pueraria lobata(Willd.) Ohwi 根部分离出来得到。它是抗氧化剂，具有显著的 ONOO(-)，NO•，总 ROS 清除活性。

8-Epideoxyloganic acid 是从 Incarvillea delavayi 中分离得到的一种环烯醚萜苷。它具有微弱的缓解疼痛活性。

Cycloolivil (Isoolivil) 是一种天然多酚化合物，在橄榄树中具有显着的自由基清除活性。 Cycloolivil 具有抗氧化活性，它可以预防与血小板过度聚集相关的血栓并发症，是开发抗聚集治疗策略的基础。

(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid 是分离自间肠隐球菌培养基的代谢物，具有高的 DPPH 清除自由基活性和抗氧化活性。