gnrh 1

GnRH Associated Peptide (GAP) (1-13), human Acetate 被发现是催乳素分泌的有效抑制剂并刺激促性腺激素的释放。用对应于 GAP 序列的肽进行主动免疫导致催乳素分泌大大增加。

GnRH Associated Peptide (GAP) (1-24), human 是人类的一个化合物，具体为促性腺激素释放激素相关肽(GAP)的第1至24个氨基酸片段(hGAP-1-24)。该化合物通过3个氨基酸加工位点与黄体生成素释放激素(LH-RH)序列连接。

GnRH-R antagonist 1 (化合物 21a) 是GnRH-R拮抗剂，具有优良口服安全性及膜透性，高亲和力结合GnRH-R（IC50=0.57 nM），并展现出有效体外拮抗活性（IC50=2.18 nM）。该化合物适用于晚期前列腺癌治疗和预防过早LH峰出现的研究。

Zebrafish Kisspeptin-1, 作为神经肽kisspeptin-1的核心序列，主要功能是参与调控促性腺激素释放激素(GnRH)的分泌，进而影响生殖系统的调节。

Phoenixin-14 (PNX-14) 是一种具有内源性活性的异构体，能通过激活AHA GnRH系统发挥抗焦虑效果，并抑制缺血 再灌注所诱导的小胶质细胞毒性。

Kisspeptin 13 是一种 GPR54和 GnRH 受体激活剂，是一种内源性的活性异构体。Kisspeptin 13 能增强记忆，可用于阿尔茨海默病的研究。

[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH 是一种黄体激素释放激素 (LHRH) 类似物，可作为 GnRH 受体拮抗剂。

sGnRH-A，一种鲑鱼促性腺激素释放激素(GnRH)类似物，能够促进生长激素的分泌，并作为人工授精中的排卵诱导剂使用。

[MePhe7]-Neurokinin B为NK-3受体(NK3R)激动剂，具有3 nM的IC50值。通过激活神经激肽3受体，[MePhe7]-Neurokinin B能够调节脉冲促性腺激素释放激素(GnRH)的分泌，成为调控该过程的潜在调节剂。

Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-54 (10-1,000 nM) inhibits insulin secretion from isolated mouse pancreatic β-cells in the presence of 2.8 mM, but not 11.1 mM, glucose.2 Kisspeptin-54 (1-5 nmol, i.c.v.) increases serum levels of luteinizing hormone (LH) and follicular stimulating hormone (FSH) in mice, an effect which is reversed by the gonadotropin releasing hormone (GNRH) antagonist acycline.3References1. Kotani, M., Detheux, M., Vandenbogaerde, A.L., et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276(37), 34631-34636 (2001).2. Vikman, J., and Ahrén, B. Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets. Diabetes Obes. Metab. 11(Suppl 4), 197-201 (2009).3. Gottsch, M.L., Cunningham, M.J., Smith, J.T., et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145(9), 4073-4077 (2004). Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-54 (10-1,000 nM) inhibits insulin secretion from isolated mouse pancreatic β-cells in the presence of 2.8 mM, but not 11.1 mM, glucose.2 Kisspeptin-54 (1-5 nmol, i.c.v.) increases serum levels of luteinizing hormone (LH) and follicular stimulating hormone (FSH) in mice, an effect which is reversed by the gonadotropin releasing hormone (GNRH) antagonist acycline.3 References1. Kotani, M., Detheux, M., Vandenbogaerde, A.L., et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276(37), 34631-34636 (2001).2. Vikman, J., and Ahrén, B. Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets. Diabetes Obes. Metab. 11(Suppl 4), 197-201 (2009).3. Gottsch, M.L., Cunningham, M.J., Smith, J.T., et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145(9), 4073-4077 (2004).

Merigolix 是一种有效的促性腺激素释放激素GnRH 拮抗剂。

[D-Lys6]-LH-RH 是一种黄体激素释放激素 (LHRH) 类似物，可作为GnRH 受体激动剂。

'(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon)' 为一种GnRH类似物，主要用于诱导养殖鱼类排卵和 或产卵。

Zoptarelin doxorubicin, also known as AEZS-108, is an LHRH agonist. Zoptarelin doxorubicin is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation

Buserelin Acetate (57982-77-1 free base) (Buserelin Acetate) 是促性腺激素释放激素受体 (GnRHR) 的激动剂。

Acyline TFA，GnRH 多肽类似物，是一种GnRH 拮抗剂，可以抑制促性腺激素和睾酮 (T) 水平。

sGnRH-A醋酸盐是一种鲑鱼促性腺激素释放激素(GnRH)类似物。它能促进生长激素的分泌，并用作人工授精时的排卵诱导剂。

GnRH Associated Peptide (GAP) (25-53), human 是来源于人的促性腺激素释放激素相关肽（GAP）的一个特定片段，具体为第25至第53位氨基酸（hGAP-25-53）。本片段可用作免疫原，用以产生含有MC-1、MC-2和MC-3等抗体的抗血清。GAP通过其内含的三个氨基酸加工位点，能与黄体生成素释放激素（LH-RH）序列进行有效连接。

Ganirelix为一种竞争性且选择性的促性腺激素释放激素(GnRH)拮抗剂，其主要作用机制为抑制内源性GnRH，从而抑制黄体生成素(LH)及促卵泡激素的释放。

Phoenixin-14 (PNX-14) TFA 是具抗焦虑、心脏保护及神经保护效果的穿透大脑屏障神经肽。它通过上调GnRH受体mRNA调控垂体促性腺激素分泌，并促进胰岛素释放。此外，Phoenixin-14 TFA保护小鼠免受缺血 再灌注(IR)伤害，通过降低ROS、提高GSH减缓氧化应激。

[D-Ala6]-LH-RH，一种黄体激素释放激素(LHRH)模拟物，充当GnRH受体的激动剂。