Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog also available. Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID:25484239
N-Hydroxypropyl-N’-(azide-PEG3)-Cy3 is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3 is a polyethylene glycol (PEG) based linker commonly employed in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a polyethylene glycol (PEG)-based linker used for the synthesis of proteolysis targeting chimeras (PROTACs) [1].
N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a polyethylene glycol (PEG)-derived linker, specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
Bis-(N,N’-amine-PEG3)-Cy5 is a PEG-derived linker compound employed for the synthesis of PROTACs. It serves as a PEG-based PROTAC linker in the chemical structure[1].
Cy5-PEG3-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimeras (PROTACs) linker, employed for the synthesis of PROTACs[1].