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N6F11

Name: N6F11
Brand: TargetMol
SKU: T77745
Price: 1300 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.76%

货号 T77745Cas号 851398-76-0

N6F11是一种新型且具有选择性和有效性的铁死亡诱导剂，具有抗癌抗肿瘤活性，通过与癌细胞中的TRIM25结合从而促进GPX4降解。N6F11 可用于研究胰腺癌。

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N6F11

一键复制产品信息

很棒

纯度: 99.76%

货号 T77745Cas号 851398-76-0

N6F11是一种新型且具有选择性和有效性的铁死亡诱导剂，具有抗癌抗肿瘤活性，通过与癌细胞中的TRIM25结合从而促进GPX4降解。N6F11 可用于研究胰腺癌。

规格	价格	库存
1 mg	¥ 1,300	现货
5 mg	¥ 3,250	现货
10 mg	¥ 4,750	现货
25 mg	¥ 7,480	现货
50 mg	¥ 9,870	现货
100 mg	¥ 13,600	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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选择批次:

纯度: 99.76%

颜色: 黄色

性状: Solid

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COA HPLC HNMR 产品操作手册

产品介绍

N6F11 AI Summary

N6F11 exhibits a diverse array of bioactivities. It is a modulator of Lamin A splicing, an inhibitor of Human Jumonji Domain Containing 2E (JMJD2E), and an activator of the Rab9 Promoter. It functions as both an inhibitor and an activator of Leishmania Mexicana Pyruvate Kinase (LmPK) and enhances SMN2 splice variant expression. Additionally, it is utilized as a counterscreen for inhibitors of ROR gamma transcriptional activity and identifies cytotoxic compounds for NIH3T3 cells. It inhibits the replication of Trypanosoma cruzi and serves as an IMPase inhibitor potentiated with lithium. N6F11 shows potential as an inhibitor of the Respiratory Syncytial Virus (RSV) and acts as an inhibitor of BAZ2B, ELG1-dependent DNA repair in HEK293T cells, HP1-beta Chromodomain interactions, TGF-beta, Polymerase Eta, and the malarial parasite plastid. It counteracts TGF-beta binding or entry into cells and inhibits Marburg Virus, Lassa Virus, and Hepatitis C Virus (HCV). The compound also induces DNA re-replication in MCF 10a normal breast cells, serves as an inverse agonist for the GLP-1 Receptor, and shows potential as an agonist for gsp mutation-related Fibrous Dysplasia/McCune-Albright Syndrome. Furthermore, it activates integrin-mediated alleviation for Muscular Dystrophy, induces synthetic lethality in tumor cells producing 2HG, and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the presence and absence of CPT. It is an inhibitor of MBNL1-poly(CUG) RNA binding and TGF-beta in various assays for cytotox counterscreens and confirmation of cherry picks..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	N6F11 is a novel, selective and potent inducer of ferroptosis with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer.

化学信息

分子量	311.19
分子式	C₁₃H₈Cl₂N₂OS
CAS No.	851398-76-0
Smiles	ClCC1=NC2=C(SC(=C2)C2=CC=C(Cl)C=C2)C(=O)N1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 22.7 mg/mL (72.95 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2135 mL	16.0674 mL	32.1347 mL	160.6735 mL
5 mM	0.6427 mL	3.2135 mL	6.4269 mL	32.1347 mL
10 mM	0.3213 mL	1.6067 mL	3.2135 mL	16.0674 mL
20 mM	0.1607 mL	0.8034 mL	1.6067 mL	8.0337 mL
50 mM	0.0643 mL	0.3213 mL	0.6427 mL	3.2135 mL

计算器

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稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。